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Nicotinamide and neurocognitive function
Nutritional Neuroscience, 2014Nicotinamide, or vitamin B3, is a precursor of nicotinamide adenine dinucleotide (NAD(+)) and is involved in a multitude of intra- and inter-cellular processes, which regulate some of the cell's metabolic, stress, and immune responses to physiological or pathological signals.
Haryana M. Dhillon +4 more
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Effects of Nicotinamide on Xenotransplantation
Transplantation Proceedings, 1998ISLET transplantation from rodents is a useful model for developing potential approaches to both xenografts and allografts in humans. One of the major obstacles to pancreatic islet transplantation is the limited yield of islets from the donor pancreas.
L. Barneo +4 more
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[1] Determination of nicotinamide
1980Publisher Summary This chapter discusses the experimental study, focusing on the determination of nicotinamide. Nicotinamide and nicotinate are generally determined, by some modification of the Koenig reaction— that is, the reaction with cyanogens bromide and an aromatic amine to give a color.
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Photoprotection by Nicotinamide
2010Nicotinamide is the primary precursor of nicotinamide adenine dinucleotide (NAD) [1], which is required for the manufacture of adenosine triphosphate (ATP) in the citric acid cycle (Fig. 11.1). Ultraviolet (UV) irradiation causes both DNA damage and depletion of cellular energy (NAD) [2], which is required for efficient DNA repair.
Diona L. Damian, Gary M. Halliday
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Photoprotective effects of nicotinamide
Photochemical & Photobiological Sciences, 2010Sun protective measures can reduce numbers of both precancerous actinic keratoses and cutaneous squamous cell carcinomas within relatively short periods of time even in high-risk populations. Sunscreens, which tend to provide greater protection against shortwave UVB than against longer wavelength UVA radiation, can however provide only partial ...
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Nicotinamide pharmacokinetics in patients
Radiotherapy and Oncology, 1995Pharmacokinetic analyses were performed on blood samples of 12 patients undergoing treatment with nicotinamide, hyperthermia and radiation therapy for a variety of recurrent/metastatic cancers. Escalating oral doses of 3, 4, 5, 6 and 10 g of nicotinamide showed a linear relationship between maximum recorded plasma concentrations and the dose in grams ...
Jadranka Dragovic +3 more
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Deamidation of nicotinamide and NMN
Biochemical and Biophysical Research Communications, 1961Deamidation of nicotinamide was first demonstrated in lactic acid bacteria by Hughes and Williamson (1953). Rajagopalan et al. (1958) were the first to report the presence of this enzyme nicotinamide deamidase in vertebrates. Among the vertebrates studied, the enzyme activity was exhibited only by the avian species. The present communication deals with,
Sarma, DSR, Rajalakshmi, S, Sarma, PS
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Psychoregulatory role of nicotinamide
Bulletin of Experimental Biology and Medicine, 1993In the experiment and clinics, psychotropic effect of nicotinamide (tranquilized and nootropic activity) has been established. It has been shown that nicotinamide in conflict situation has anxiolytic effect, increase aggressive reaction threshold, decrease the quantity of induced fights during interspecies' incompatibility modelling.
R. A. Gadzhily +3 more
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Nicotinamide and Diabetes Prevention
Nutrition Reviews, 2009Individuals at high risk of developing insulin-dependent diabetes mellitus can now be identified by immunologic testing. This ability to predict future cases of IDDM raises the possibility of intervention to prevent the disease. An intervention study in New Zealand using nicotinamide treatment showed a 50% reduction in the development of IDDM in a 5 ...
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Use of nicotinamide in dermatology
Clinical and Experimental Dermatology, 2017Nicotinamide (niacinamide) is the water-soluble, amide form of vitamin B3. We review the evidence underlying the use of nicotinamide for various dermatological indications, including nonmelanoma cancer prophylaxis, blistering disorders, acne vulgaris and cosmetic indications, and speculate upon its future role in dermatological practice.
E. Forbat, F. Al-Niaimi, F. R. Ali
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