Results 281 to 290 of about 107,918 (341)

Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets. [PDF]

J Neurotrauma, 2017
von Leden RE, Yauger YJ, Khayrullina G, Byrnes KR.   +3 more
europepmc   +1 more source

Multiple regulatory processes in nicotinamide adenine dinucleotide-specific glutamic dehydrogenases. Catabolite repression; nicotinamide adenine dinucleotide phosphate, reduced nicotinamide adenine dinucleotide phosphate, and phosphoenolpyruvate as activators; allosteric inhibition by substrates.

The Journal of biological chemistry, 1971
H B, LéJohn, R M, Stevenson
openaire   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

Houston, we have a problem: Coagulation concerns during long‐term spaceflight

Experimental Physiology, EarlyView.
Lewis Fall, Damian M. Bailey
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Molecular basis and biological relevance of bacterial and plant pinoresinol/lariciresinol reductase specificities

Protein Science, Volume 35, Issue 2, February 2026.
Abstract A bacterial pinoresinol/lariciresinol reductase (PLR) homolog named NrPinZ was obtained from a Novosphingobium rhizosphaerae sp. LY bacterial strain, with NrPinZ being part of its 5‐step biochemical system catabolizing pinoresinol into coniferyl aldehyde and vanillin.
Clyde A. Smith, Diana L. Bedgar, Michael A. Costa, Syed G. A. Moinuddin, Marco N. Allemann, Joshua K. Michener, Laurence B. Davin, Norman G. Lewis   +7 more
wiley   +1 more source

A Novel Link Between Electron Transport Chain Modulation and mcl‐PHA Production in Pseudomonas aeruginosa 5300 Using Azide as a Modulator

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
The oleic acid and azide inhibited the cytochrome c oxidase activity in Pseudomonas aeruginosa MCC 5300, shifting the electron flux towards bd‐oxidase. This resulted in more NADH consumption to maintain the proton gradient for energy generation. The rapid depletion of NADH triggered high mcl‐PHA accumulation.
Raghavendra Paduvari, Divyashree Somashekara   +1 more
wiley   +1 more source

The Relations Between Lactate Production, Respiration and Nuclear Damage in Irradiated Rat Thymocytes. EUR 2623. [PDF]

, 1965
Brohee, H., Whitfield, J.F., Youdale, T.
core