Results 291 to 300 of about 107,918 (341)

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

A Scalable Organoid Model of Urothelial Aging for Metabolic Interrogation, Infection Modeling, and Reversal of Age‐Associated Changes

Aging Cell, Volume 25, Issue 2, February 2026.
mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Adwaita R. Parab, Arnold M. Salazar, Steven J. Bark, Margarita Divenko, Vasanta Putluri, D'Feau J. Lieu, Aadya S. Singh, Nagireddy Putluri, Indira U. Mysorekar   +8 more
wiley   +1 more source

Transcriptomic, proteomic and biochemical comparison of luminescent and non‐luminescent Keroplatinae larvae (Diptera: Keroplatidae)

Insect Molecular Biology, Volume 35, Issue 1, Page 34-47, February 2026.
Transcriptomic and proteomic comparison of luminescent O. fultoni and non‐luminescent Neoditomyia sp show that the substrate binding fraction (SBF) has a similar abundance of hexamerins and the presence of flavin‐dependent reductases. In addition to the high content of keroplatin, SBF also contains considerable amounts of riboflavin and displays ...
Jaqueline R. Silva, Gabriel F. Pelentir, Danilo T. Amaral, Cassius Stevani, Vadim R. Viviani   +4 more
wiley   +1 more source

He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation <i>in vivo</i> and <i>in vitro</i>. [PDF]

World J Hepatol
Zeng FL, Shi MJ, Mo YS, Xiao HM, Xie YB, Chi XL.   +5 more
europepmc   +1 more source

THE 21-HYDROXYSTEROID DEHYDROGENASES OF LIVER. A NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE AND TWO NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASES.

The Journal of biological chemistry, 1996
C, MONDER, A, WHITE
openaire   +1 more source

Predictive value of biomarkers for tubulointerstitial and glomerular interactions in diabetic nephropathy. [PDF]

World J Nephrol
Alamilla-Sanchez M, Yama Estrella MB, Morales López EF, Delgado Pineda D.   +3 more
europepmc   +1 more source

Plasma nicotinamide adenine dinucleotide pathway depletion is linked to diastolic dysfunction in patients with advanced chronic liver disease. [PDF]

Cardiovasc Res
Gill M, O'Sullivan JF, Guglielmi G, Slaughter E, Liu RP, Hunyor I, Moss S, McGrady M, Wilcox I, McCaughan GW, Majumdar A.   +10 more
europepmc   +1 more source

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Reaction of peroxidase with reduced nicotinamide-adenine dinucleotide and reduced nicotinamide-adenine dinucleotide phosphate

Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
Summary 1. Peroxidase (donor:H2O2 oxidoreductase, EC 1.11.1.7) catalyzes the aerobic oxidation of NADH and NADPH at acidic pH in the absence of cofactors such as Mn2+ and monophenols. 2. Peroxidase Compound III appears during the reaction and disappears when almost all the oxygen in the reaction solution has been consumed. 3.
K, Yokota, I, Yamazaki
openaire   +2 more sources