Results 71 to 80 of about 107,918 (341)

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH [PDF]

, 2013
To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by- case basis with varying degrees of success.
Arnold, Frances H., Brinkmann-Chen, Sabine, Brustad, Eric M., Cahn, Jackson K. B., Flock, Tilman, McIntosh, John A., Meinhold, Peter, Snow, Christopher D., Zhang, Liang   +8 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Is there an interplay between adherence to mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients? [PDF]

, 2016
Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known.
Cristina Nocella, Daniele Pastori, Danilo Menichelli, Francesco Violi, Isabella Leo, Marta Novo, Pasquale Pignatelli, Roberto Carnevale, Simona Bartimoccia   +8 more
core   +6 more sources

Evaluation of rate law approximations in bottom-up kinetic models of metabolism. [PDF]

, 2016
BackgroundThe mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters.
A Bordbar, A Dräger, A Flamholz, A Joshi, A Kinoshita, AB Canelas, Andreas Dräger, AR Tzafriri, BD Bennett, Bernhard O. Palsson, Bin Du, BO Palsson, BO Palsson, C Chassagnole, D Visser, D Visser, DA Fell, Daniel C. Zielinski, E Noor, Erol S. Kavvas, F Hadlich, Garri A. Arzumanyan, GE Briggs, J Almquist, J Schellenberger, JJ Heijnen, JR Karr, Justin Tan, K Smallbone, K Takahashi, Kayla E. Ruggiero, KR Sanft, LA Segel, LA Segel, M Bier, M Salter, M Scheer, N Jamshidi, N Jamshidi, N Jamshidi, N Zamboni, O Kotte, PJ Mulquiney, R Grima, S Schnell, SA Becker, U Alon, W Liebermeister, Y-Y Liu, Zhen Zhang   +49 more
core   +4 more sources

Is Nicotinamide Adenine Dinucleotide Phosphate an Obligatory Intermediate in Photosynthesis? [PDF]

Plant Physiology, 1972
The site of action of the inhibitors disalicylidenepropanediamine and pyrophosphate was more closely defined as acting on ferredoxin. Three inhibitors which act on the electron transport path between ferredoxin and NADP: disalicylidenepropanediamine, pyrophosphate, and phosphoadenosinediphosphate ribose, had no effect on photosynthesis in cell free ...
A, Ben-Amotz, M, Avron
openaire   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

eLife, 2018
We introduce a new class of semisynthetic fluorescent biosensors for the quantification of free nicotinamide adenine dinucleotide (NAD+) and ratios of reduced to oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) in live cells. Sensing is
Olivier Sallin, Luc Reymond, Corentin Gondrand, Fabio Raith, Birgit Koch, Kai Johnsson   +5 more
doaj   +1 more source

Direct wiring of redox cofactors onto gold electrodes via inorganic iron-sulfur clusters enhances charge transport

Biosensors and Bioelectronics: X, 2022
Inorganic iron-sulfur clusters (Fe–S) have emerged as potential electrode anchors and electron shuttles for enzymatic biosensor systems involving nicotinamide adenine dinucleotide (NAD) cofactor.
Aishwarya Mahadevan, StanislavV. Verkhoturov, Sreeram Vaddiraju, Mathew Pietz, Peter Di Carlo, Sandun Fernando   +5 more
doaj   +1 more source

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway [PDF]

, 2014
published_or_final_versio
Graeff, RM, Wei, W, Yue, J
core   +1 more source

Cryo‐EM of Rationally Designed Photosystem I Nanoassembly on Graphene Validates Orientation‐Driven Enhancement of Photocatalytic Performance

Advanced Functional Materials, EarlyView.
The first cryo‐EM visualization and quantification of oriented Photosystem I (PSI) on single‐layer graphene is reported. Domain‐specific covalent anchoring of PSI, with the reducing side of the biophotocatalyst toward graphene, promotes three‐fold higher anodic photocurrent generation compared to a randomly physisorbed counterpart. This approach allows
Miriam Izzo, Margot Jacquet, Tomasz Góral, Marcin Strawski, Takayuki Fujiwara, Shin‐ya Miyagishima, Joanna Kargul   +6 more
wiley   +1 more source