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Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin

Comprehensive Physiology, 2017
ABSTRACTNicotinamide phosphoribosyltransferase (NAMPT) is an adipokine‐enzyme, which was described as to play bioactivities both in the intracellular and in the extracellular environment. However, while the functions of intracellular NAMPT (iNAMPT) are well known, much less is known on extracellular NAMPT (eNAMPT), also called visfatin or pre‐B cell ...
Carbone F.   +10 more
openaire   +2 more sources

Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase

The Journal of Biochemistry, 2009
Nicotinamide (NM) phosphoribosyltransferase (NMPRTase) catalyzes the reaction of NM and 5'-phosphoribosyl-1'-pyrophosphate (PRPP) to form NM mononucleotide (NMN) and pyrophosphate (PPi) in the pathway of NAD-biosynthesis. Monitoring the (1)H and (31)P NMR spectra of the reaction mixture, we found that this reaction is reversible as dictated by the ...
Ryo, Takahashi   +7 more
openaire   +2 more sources

Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas

APMIS, 2011
Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011; 119: 296–303.The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic
Olesen, Uffe Høgh   +2 more
openaire   +3 more sources

The Role of Nicotinamide Phosphoribosyltransferase in Pregnancy: A Review

American Journal of Perinatology, 2016
Nicotinamide phosphoribosyltransferase (NAMPT) was first reported in 1994 and has been explored in various human disease processes. However, until recently, very little has been done to define the role of NAMPT in pregnancy. NAMPT is a 52 kDa protein that has diverse functions in the human body, acting as a growth factor, cytokine, an enzyme, and an ...
Blake, Porter   +3 more
openaire   +2 more sources

Nicotinamide phosphoribosyltransferase in wound healing

The American Journal of the Medical Sciences, 2023
A Izadpanah, J Rappaport
openaire   +1 more source

[117] Nicotinamide phosphoribosyltransferase from rat liver

1971
Publisher Summary This chapter focuses on the assay method, purification procedure, and properties of the enzyme nicotinamide phosphoribosyltransferase from rat liver. The method is based on the chromatographic separation of the reaction product, 14 C-labeled nicotinamide mononucleotide, from the substrate 14 C-labeled nicotinamide.
openaire   +1 more source

[Nicotinamide phosphoribosyltransferase and its roles in cancer].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2014
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells. Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor, induces B-cell differentiation, inhibits neutrophil apoptosis, and affects immune ...
Xiao-fang, Xu, Ming, Wu
openaire   +1 more source

Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages.

European journal of clinical investigation, 2012
Accumulation of modified low-density lipoprotein (LDL) in macrophages is a key event in all stages of atherogenesis. We have previously shown increased level of nicotinamide phosphoribosyltransferase (nampt) in symptomatic, compared to asymptomatic, atherosclerotic carotid lesions, primarily located to macrophages.
Tuva, Dahl   +5 more
openaire   +1 more source

Nicotinamide phosphoribosyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

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