Results 141 to 150 of about 57,446 (263)

Serum Visfatin Level and Cardiac Valve Calcifcation in Hemodialysis Patients

Hemodialysis International, Volume 30, Issue 1, Page 101-109, January 2026.
ABSTRACT Background Cardiac valve calcification is a serious complication in patients with cardiovascular disease. This study investigated the relationship between visfatin levels and cardiac valve calcification in individuals undergoing hemodialysis.
Xiaoqi Wang, Dan Yuan, Feng Shao, Conghui Liu, Xiao Zhang, Zhongxin Li   +5 more
wiley   +1 more source

Gene regulation and epigenotype in Friedreich's ataxia [PDF]

, 2008
Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core   +2 more sources

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

Genistein enhances NAD ⁺ biosynthesis by binding to Prohibitin 1 and upregulating nicotinamide phosphoribosyltransferase in adipocytes [PDF]

, 2023
Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani   +6 more
openalex   +1 more source

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. [PDF]

, 2002
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity.
Frye, Roy A, North, Brian J, Ott, Melanie, Schwer, Bjorn, Verdin, Eric   +4 more
core  

Function of NAD metabolism in white adipose tissue: lessons from mouse models

Adipocyte
Nicotinamide Adenine Dinucleotide (NAD) is an endogenous substance in redox reactions and regulates various functions in metabolism. NAD and its precursors are known for their anti-ageing and anti-obesity properties and are mainly active in the liver and
So Young Kwon, Yoon Jung Park
doaj   +1 more source

Supplementary Information from Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma

, 2023
Christine M. Heske, Mindy I. Davis, Joshua T. Baumgart, Kelli M. Wilson, Michael V. Gormally, Lu Chen, Xiaohu Zhang, Michele Ceribelli, Damien Duveau, Rajarshi Guha, Marc Ferrer, Fernanda I. Arnaldez, Jiuping Ji, Huong-Lan Tran, Yiping Zhang, Arnulfo Mendoza, Lee J. Helman, Craig J. Thomas   +17 more
openalex   +1 more source

Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]

, 2016
Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina, Pertusati, Fabrizio, Serpi, Michaela   +2 more
core   +1 more source

News Letter of Frontier Research Core for the Life Sciences, University of Toyama [PDF]

, 2012
「富山発先端ライフサイエンス若手育成拠点」事業は，4年度目となり，着実に成果を出し，事業を進めている。今号では平成26年の年頭にあたることから，学長より拠点事業の目指すところを示すお言葉を頂いた。引き続き，テニュアトラック教員の研究紹介と今年度の事業取組である"産業連携スキルの向上"と"拠点シンポジウム"の実施の様子を掲載している。今後とも，テニュアトラック教員及び本事業にご理解とご支援のほど ...
富山大学先端ライフサイエンス拠点
core   +4 more sources