Results 151 to 160 of about 57,446 (263)

Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]

, 2015
We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert, Ingle, Shakti, Tullius, Tom   +2 more
core   +3 more sources

Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator

, 2021
Mayuko Akiu, Takashi Tsuji, Kouki Iida, Yoshitaka Sogawa, Koji Terayama, Mika Yokoyama, Jun Tanaka, Daigo Asano, Tomohiro Honda, Ken Sakurai, Anthony B. Pinkerton, Tsuyoshi Nakamura   +11 more
openalex   +2 more sources

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation. [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP ...
Chen, Jingwen, Cheng, Qinqin, Dai, Zhefu, Evdokimov, Nikolai M, Lam, Albert T, Louie, Stan G, Lu, Yanran, Pei, Hua, Zhang, Xiao-Nan, Zhang, Yong   +9 more
core   +1 more source

Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages [PDF]

, 2016
Bacterial lipopolysaccharide induces changes in intracellular NAD+ levels in a pro-inflammatory, but not an anti-inflammatory, macrophage model that are correlated with the release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α).
Abbas Jawad Al-Shabany, Al-Abady, Alan John Moody, Andrew David Foey, Bieganowski, Bruzzone, Daigneault, Dietl, Fedele, Ferrero, Finlay, Galvan-Pena, Holen, Horwitt, Hotamisligil, Howard, Iqbal, Leonardo, Livak, Maciver, Magni, Magni, Murray, Park, Remer, Revollo, Richard Andrew Billington, Riebel, Rongvaux, Schertzer, Schilling, Schwende, Shubinsky, Sutherland, Tavakoli, Van Gool   +35 more
core   +2 more sources

Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death

Cell Reports, 2017
Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) is the rate-limiting enzyme of the mammalian NAD+ biosynthesis salvage pathway. Using inducible and conditional knockout (cKO) mice, we show that Nampt gene deletion in adult projection ...
Xiaowan Wang, Qiao Zhang, Ruisi Bao, Nannan Zhang, Yingzhen Wang, Luis Polo-Parada, Andrew Tarim, Aidan Alemifar, Xianlin Han, Heather M. Wilkins, Russell H. Swerdlow, Xinglong Wang, Shinghua Ding   +12 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy [PDF]

, 2018
Changgui Shi, Huiqiao Wu, Di Du, Hee‐Jeong Im, Ying Zhang, Bo Hu, Huajiang Chen, Xinwei Wang, Yang Liu, Peng Cao, Ye Tian, Xiaolong Shen, Rui Gao, André J. van Wijnen, Xiaojian Ye, Y. Edward Wen   +15 more
openalex   +1 more source

Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience

Current Drug Targets, 2013
Nicotinamide adenine dinucleotide (NAD+) biosynthesis from nicotinamide is used by mammalian cells to replenish their NAD+ stores and to avoid unwanted nicotinamide accumulation. Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the key enzyme in this biosynthetic pathway, almost invariably leads to intracellular NAD ...
MONTECUCCO, FABRIZIO, CEA, MICHELE, Bauer I, SONCINI, DEBORA, CAFFA, IRENE, Lasigliè D, Nahimana A, UCCELLI, ANTONIO, BRUZZONE, SANTINA, NENCIONI, ALESSIO   +9 more
openaire   +3 more sources

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Blood Advances
: Elevated levels of the NAD+-generating enzyme nicotinamide phosphoribosyltransferase (NAMPT) are a common feature across numerous cancer types.
Debora Soncini, Pamela Becherini, Francesco Ladisa, Silvia Ravera, Adithya Chedere, Elisa Gelli, Giulia Giorgetti, Claudia Martinuzzi, Francesco Piacente, Luca Mastracci, Claudia Veneziano, Gianluca Santamaria, Fiammetta Monacelli, Moustafa S. Ghanem, Antonia Cagnetta, Fabio Guolo, Matteo Garibotto, Sara Aquino, Mario Passalaqua, Santina Bruzzone, Axel Bellotti, Michel A. Duchosal, Aimable Nahimana, Emanuele Angelucci, Chandra Nagasuma, Alessio Nencioni, Roberto Massimo Lemoli, Michele Cea   +27 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease [PDF]

, 2017
Alanna Watson, Zengxuan Nong, Hao Yin, Caroline O’Neil, Stephanie A. Fox, Brittany Balint, Linrui Guo, Oberdan Léo, Michael Chu, Robert Gros, J. Geoffrey Pickering   +10 more
openalex   +1 more source