Results 151 to 160 of about 51,366 (193)

Correction: Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer. [PDF]

J Immunother Cancer
europepmc   +1 more source

Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models. [PDF]

Mol Med Rep, 2019
Xing S, Hu Y, Huang X, Shen D, Chen C.
europepmc   +1 more source

Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase

, 2008
Emmanuel S. Burgos, Vern L. Schramm
openalex   +1 more source

Increased Nicotinamide Phosphoribosyltransferase in Rhabdomyosarcomas and Leiomyosarcomas Compared to Skeletal and Smooth Muscle Tissue.

, 2016
Moiz Vora, Junaid Ansari, Rabie M. Shanti, Diana M. Veillon, James D. Cotelingam, Domenico Coppola, Rodney E. Shackelford   +6 more
openalex   +1 more source

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Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell Lung Cancer.

Journal of Medicinal Chemistry, 2023
Depleting NAD+ by blocking its biosynthesis has emerged as an attractive anticancer strategy. Simultaneous blockade of NAD+ production from the salvage and de novo synthesis pathways by targeting NAMPT and IDO1 could achieve more effective NAD+ reduction
Kaizhen Wang, Ke Ye, Xiangyu Zhang, Tianyu Wang, Zhihao Qi, Youjun Wang, Sheng Jiang, Kuojun Zhang   +7 more
semanticscholar   +1 more source

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).

Journal of Medicinal Chemistry, 2022
Autophagosome-tethering compounds (ATTECs) are an emerging new technology in targeted protein degradation. However, effective tools and successful examples for autophagosome-tethering chimeras are still rather limited.
Guoqiang Dong, Ying Wu, Junfei Cheng, Long Chen, R. Liu, Yu Ding, Shanchao Wu, Junhui Ma, C. Sheng   +8 more
semanticscholar   +1 more source

Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.

Journal of Medicinal Chemistry, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) is identified as a promising target for cancer therapy. However, known NAMPT inhibitors are characterized by weak clinical efficacy and dose-dependent toxicity.
Kaijian Bi, Junfei Cheng, Shipeng He, Yuxin Fang, Min Huang, C. Sheng, Guoqiang Dong   +6 more
semanticscholar   +1 more source

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer.

Journal of Medicinal Chemistry, 2022
Targeting NAD+ metabolism has emerged as an effective anticancer strategy. Inspired by the synergistic antitumor effect between NAD(P)H:quinone oxidoreductase 1 (NQO1) substrates increasing the NAD consumption and nicotinamide phosphoribosyltransferase ...
Kuojun Zhang, Kaizhen Wang, Xiangyu Zhang, Zhenlong Qian, Wenbo Zhang, Xiao Zheng, Jiaying Wang, Ying Jiang, Wanheng Zhang, Zhiyu Lu, H. Hao, Sheng Jiang   +11 more
semanticscholar   +1 more source