Results 211 to 220 of about 57,446 (263)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma

, 2018
Valentina Audrito, Antonella Managò, Federica Zamporlini, Eliana Rulli, Federica Gaudino, Gabriele Madonna, Stefania D’Atri, Gian Carlo Antonini Cappellini, Paolo A. Ascierto, Daniela Massi, Nadia Raffaelli, Mario Mandalà, Silvia Deaglio   +12 more
openalex   +2 more sources

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma
Nicotinamide (Nam) phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in mammalian NAD synthesis, catalyzing nicotinamide mononucleotide (NMN) formation from Nam and 5-phosphoribosyl 1-pyrophosphate (PRPP). NAMPT has also been described as an adipocytokine visfatin with a variety of actions, although physiological significance of this ...
openaire  

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors

, 2013
Xiaozhang Zheng, Timm Baumeister, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Bingsong Han, Yen‐Ching Ho, Nikolai Kley, Jian Lin, Dominic J. Reynolds, Geeta Sharma, Chase C. Smith, Zhongguo Wang, Peter S. Dragovich, Angela Oh, Weiru Wang, Mark Zak, Yunli Wang, Po‐wai Yuen, Kenneth W. Bair   +19 more
openalex   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Nicotinamide phosphoribosyltransferase in wound healing

The American Journal of the Medical Sciences, 2023
A. Izadpanah, J. Rappaport
semanticscholar   +2 more sources

Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell Lung Cancer.

Journal of Medicinal Chemistry, 2023
Depleting NAD+ by blocking its biosynthesis has emerged as an attractive anticancer strategy. Simultaneous blockade of NAD+ production from the salvage and de novo synthesis pathways by targeting NAMPT and IDO1 could achieve more effective NAD+ reduction
Kaizhen Wang, Ke Ye, Xiangyu Zhang, Tianyu Wang, Zhihao Qi, Youjun Wang, Sheng Jiang, Kuojun Zhang   +7 more
semanticscholar   +1 more source

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).

Journal of Medicinal Chemistry, 2022
Autophagosome-tethering compounds (ATTECs) are an emerging new technology in targeted protein degradation. However, effective tools and successful examples for autophagosome-tethering chimeras are still rather limited.
Guoqiang Dong, Ying Wu, Junfei Cheng, Long Chen, R. Liu, Yu Ding, Shanchao Wu, Junhui Ma, C. Sheng   +8 more
semanticscholar   +1 more source

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

Journal of Medicinal Chemistry, 2013
Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics and in the regulation of NAD-using enzymes, such as PARPs and sirtuins. Furthermore, there is now ample evidence that NAMPT is secreted and has a role as a cytokine.
GALLI, Ubaldina, TRAVELLI, Cristina, MASSAROTTI, Alberto, Fakhfouri, G, Rahimian, R, TRON, Gian Cesare, GENAZZANI, Armando   +6 more
openaire   +4 more sources

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer.

Journal of Medicinal Chemistry, 2022
Targeting NAD+ metabolism has emerged as an effective anticancer strategy. Inspired by the synergistic antitumor effect between NAD(P)H:quinone oxidoreductase 1 (NQO1) substrates increasing the NAD consumption and nicotinamide phosphoribosyltransferase ...
Kuojun Zhang, Kaizhen Wang, Xiangyu Zhang, Zhenlong Qian, Wenbo Zhang, Xiao Zheng, Jiaying Wang, Ying Jiang, Wanheng Zhang, Zhiyu Lu, H. Hao, Sheng Jiang   +11 more
semanticscholar   +1 more source

A rapid procedure for assaying nicotinamide phosphoribosyltransferase

Analytical Biochemistry, 1980
Abstract A precipitation-filtration assay which measures the activity of nicotinamide phosphoribosyltransferase is described. The assay, based on the differential solubility of nicotinamide and nicotinamide mononucleotide in acetone, is rapid, convenient, and inexpensive when compared to chromatographic methods.
G C, Elliott, J, Ajioka, C Y, Okada
openaire   +2 more sources