Results 221 to 230 of about 57,446 (263)

Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase.

Journal of Medicinal Chemistry
Nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic target for treating select cancers. There are two forms of NAMPT: intracellular NAMPT (iNAMPT, the rate-limiting enzyme in the mammalian NAD+ main synthetic pathway) and ...
Tiangong Lu, Fangfang Chen, Jian Yao, Zixuan Bu, A. Kyani, Benji Liang, Shaoting Chen, Yuxiang Zheng, Hong Liang, Nouri Neamati, Yanghan Liu   +10 more
semanticscholar   +1 more source

MicroRNA-26b Reduces Cell Viability by Inhibition of Nicotinamide Phosphoribosyltransferase in Breast Cancer Cells

DNA and Cell Biology, 2022
Breast cancer (BC) is one of the most common causes of cancer in women worldwide and it is found to be associated with an increased level of Nicotinamide phosphoribosyltransferase (NAMPT), which plays an important role in nicotinamide adenine ...
Melika Ameli Mojarad, Mandana Ameli Mojarad, Alireza Pourmahdian   +2 more
semanticscholar   +1 more source

Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions.

Journal of Medicinal Chemistry
Nicotinamide adenine dinucleotide (NAD+) plays a crucial role in the cellular energy metabolism pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme involved in the biosynthesis of NAD+.
Sicheng Yang, Donghuan Sun, Ying Wu, Shuqiang Chen, Yuan Guo, Jian Li, Guoqiang Dong, Chunquan Sheng   +7 more
semanticscholar   +1 more source

Nicotinamide phosphoribosyltransferase regulates cocaine reward through Sirtuin 1

Experimental Neurology, 2018
Nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis in mammals, converts nicotinamide into nicotinamide mononucleotide (NMN). NMN is subsequently converted to NAD, a component that is critical for cell energy metabolism and survival.
Jueying Kong, Changman Du, Linhong Jiang, Wei Jiang, Pengchi Deng, Xue Shao, Baolai Zhang, Yan Li, Ruiming Zhu, Qian Zhao, Dengqi Fu, Hui Gu, Li Luo, Hailei Long, Yinglan Zhao, Xiaobo Cen   +15 more
openaire   +2 more sources

Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities

Expert Review of Anticancer Therapy, 2016
Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme that catalyzes the first step in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Aberrant NAD metabolism was associated with oncogenic signal transduction, suggesting the critical roles of Nampt in tumorigenesis and metastasis.
Hang, Chen, Shiyu, Wang, Haiyuan, Zhang, Edouard C, Nice, Canhua, Huang   +4 more
openaire   +2 more sources

Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin

Comprehensive Physiology, 2017
ABSTRACTNicotinamide phosphoribosyltransferase (NAMPT) is an adipokine‐enzyme, which was described as to play bioactivities both in the intracellular and in the extracellular environment. However, while the functions of intracellular NAMPT (iNAMPT) are well known, much less is known on extracellular NAMPT (eNAMPT), also called visfatin or pre‐B cell ...
Carbone F., Liberale L., Bonaventura A., Vecchiè A., Casula M., Cea M., Monacelli F., Caffa I., Bruzzone S., Montecucco F., Nencioni A.   +10 more
openaire   +2 more sources

Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase

The Journal of Biochemistry, 2009
Nicotinamide (NM) phosphoribosyltransferase (NMPRTase) catalyzes the reaction of NM and 5'-phosphoribosyl-1'-pyrophosphate (PRPP) to form NM mononucleotide (NMN) and pyrophosphate (PPi) in the pathway of NAD-biosynthesis. Monitoring the (1)H and (31)P NMR spectra of the reaction mixture, we found that this reaction is reversible as dictated by the ...
Ryo, Takahashi, Shota, Nakamura, Takashi, Nakazawa, Katsuhiko, Minoura, Takuya, Yoshida, Yoshinori, Nishi, Yuji, Kobayashi, Tadayasu, Ohkubo   +7 more
openaire   +2 more sources

Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas

APMIS, 2011
Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011; 119: 296–303.The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic
Olesen, Uffe Høgh, Hastrup, Nina, Sehested, Maxwell   +2 more
openaire   +3 more sources

The Role of Nicotinamide Phosphoribosyltransferase in Pregnancy: A Review

American Journal of Perinatology, 2016
Nicotinamide phosphoribosyltransferase (NAMPT) was first reported in 1994 and has been explored in various human disease processes. However, until recently, very little has been done to define the role of NAMPT in pregnancy. NAMPT is a 52 kDa protein that has diverse functions in the human body, acting as a growth factor, cytokine, an enzyme, and an ...
Blake, Porter, Shilpa, Babbar, Shui Qing, Ye, Dev, Maulik   +3 more
openaire   +2 more sources

[117] Nicotinamide phosphoribosyltransferase from rat liver

1971
Publisher Summary This chapter focuses on the assay method, purification procedure, and properties of the enzyme nicotinamide phosphoribosyltransferase from rat liver. The method is based on the chromatographic separation of the reaction product, 14 C-labeled nicotinamide mononucleotide, from the substrate 14 C-labeled nicotinamide.
openaire   +1 more source