Results 131 to 140 of about 210,777 (258)

Epigenetic Predictors of Smoking: External Validation and Association With Smoking‐Related Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm‐based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm‐based smoking predictors in a large sample of middle‐aged and older Australians for (i) their accuracy and reliability, and (ii) their ...
Xiaoyu Fan, Danmeng Lily Li, Allison M. Hodge, Julie K. Bassett, Nina Afshar, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre‐Antoine Dugué   +8 more
wiley   +1 more source

Building families—Implementing balanced sexual and reproductive health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu, Edgar Mocanu, Linda Giudice, Marcos Horton, Meletios P. Nigdelis, Antti Perheentupa, Andrea Sansone, Giovanni Corona, Luca Gianaroli, Dimitrios G. Goulis   +9 more
wiley   +1 more source

Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber

iMeta, EarlyView.
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu, Qianru Gao, Junmin Hui, Mengqiong Wang, Haiyan Gao, Kai Li, Junping Zheng, Zhe Dai, Songlin Liu, Hongtao Liu   +9 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Measuring Treatment Effectiveness in Real‐World Substance Use Care: A Community‐Based Program Evaluation

Journal of Addictions &Offender Counseling, EarlyView.
ABSTRACT This study reports findings from a community‐based program evaluation examining treatment effectiveness in a real‐world outpatient substance use care setting. Using a within‐program pre–post design, changes in alcohol and drug use were assessed among clients receiving intensive outpatient services.
Jessie A. Brown, Taryn M. Akgul, Todd F. Lewis, Patti Senn   +3 more
wiley   +1 more source

Taking Jobs and Doing Harm

Journal of Applied Philosophy, EarlyView.
ABSTRACT In popular discourse and in the philosophical literature there is almost no reflection on the morality of doing harm in the context of doing one's job. To the contrary, workers are valorised simply for having a job, and typically individual workers are spared from blame, even when they cause significant harm as part of their job.
Theron Pummer, Benjamin Sachs‐Cobbe
wiley   +1 more source

Developmental and Behavioral Effects of Arsenobetaine in Zebrafish (Danio rerio)

Journal of Applied Toxicology, EarlyView.
ABSTRACT Arsenobetaine (AsB) is a prevalent organoarsenical in aquatic environments and is generally regarded as nontoxic. Despite its widespread occurrence, the developmental and neurobehavioral toxicity of AsB has not been systematically investigated.
Sravan Kumar Putnala, Prerita Sharma, Prannav Jain, Samira Leila Baldin, Owen Luo, A. K. M. Munzurul Hasan, Md Helal Uddin, Mahesh Rachamalla, Som Niyogi   +8 more
wiley   +1 more source

Diaphragm Ultrasonography Reveals Progressive Changes in Diaphragmatic Function, Morphology, and Muscle Trophism During Invasive Mechanical Ventilation in Children

Journal of Clinical Ultrasound, EarlyView.
Diaphragm ultrasonography detected progressive structural and functional deterioration in mechanically ventilated children. Prolonged invasive mechanical ventilation and neuromuscular blocking agent use were associated with ventilator‐induced diaphragmatic dysfunction, highlighting ultrasound as a valuable bedside tool to support individualized ...
Juliana Bezerra dos Santos, Emmerson Carlos Franco de Farias, Mary Lucy Ferraz Maia Fiuza de Mello, Rodrigo Santiago Barbosa Rocha   +3 more
wiley   +1 more source

Acute Effects of Smoking and Vaping on Markers of Vascular Function via Quantitative MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background E‐cigarettes contribute to endothelial dysfunction, a known cause of systemic atherosclerotic disease that cannot be adequately characterized by a single physiological parameter measured at a single vascular bed. Purpose/Hypothesis Quantify and compare acute effects of smoking or vaping with tobacco cigarettes (t‐cigs), nicotinized ...
Marianne Nabbout, Mahdie Hosseini, Harris Quach, Michael C. Langham, Alessandra S. Caporale, Wensheng Guo, Kathryn Jaroszynski, Frank T. Leone, Andrew A. Strasser, Felix W. Wehrli   +9 more
wiley   +1 more source

Twenty‐four month clinical outcomes of modified coronally advanced tunnel technique with leukocyte‐ and platelet‐rich fibrin–functionalized porcine dermal matrix for single/multiple gingival recessions

Journal of Periodontology, EarlyView.
Abstract Background To report 24‐month clinical and 3D outcomes of single and multiple RT1 and RT2 gingival recessions treated with the modified coronally advanced tunnel (MCAT) technique and an L‐PRF‐functionalized porcine dermal matrix (PDM), as long‐term data on PDM in root coverage are scarce.
Erik Würflein, Katharina Herrmann, Anton Sculean, Kirstin Vach, Katja Nelson, Tobias Fretwurst, Gerhard Iglhaut, Florian Kernen   +7 more
wiley   +1 more source