Results 111 to 120 of about 210,777 (258)
Clinical Pharmacology &Therapeutics, EarlyView.Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer +10 more
wiley +1 more source
Association between self-esteem and nicotine dependence in adolescents
, 2017 SIGNIFICANCE: Early onset of nicotine dependence is associated with sustained and frequent smoking in adulthood and significant health consequences.
Lam, TH +4 more
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Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Developmental Dynamics, EarlyView.Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
ToxicsElectronic cigarettes are widely used as alternatives to conventional cigarettes. However, the relationships among e-liquid formulation, nicotine volatility, and nicotine delivery remain insufficiently investigated due to limited data on nicotine vapor ...
Kaiyuan Wang, Xue Gong
doaj +1 more source
Nicotine and its effects on periodontal tissue
, 2018 Nicotine, the chief active ingredient of tobacco, has been known since the introduction of the plant in Europe in the middle sixteenth century. Nicotine can be found in some vegetables consumed in every-day life such as eggplant, cauliflower, green ...
Bassey-Duke, Amanda
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A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)
Developmental Dynamics, EarlyView.Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble +2 more
wiley +1 more source
GP prescribing of nicotine replacement and bupropion to aid smoking cessation in England and Wales [PDF]
, 2004 Aims Prescribing nicotine replacement therapy (NRT) or bupropion for smoking cessation is of considerable importance to public health but little is known about prescribing practices.
McEwen, A, Owen, L, West, R
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Menthol cigarette smoking and nicotine dependence
, 2011 Since tobacco use is driven by dependence on nicotine, the primary addictive substance in tobacco, much research has focused on nicotine dependence. Less well understood, however, is the role that menthol plays in nicotine dependence.
Dee Simmons +2 more
core +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning +2 more
wiley +1 more source