Results 91 to 100 of about 210,777 (258)

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Associations of demographic and tobacco use characteristics with young adults’ self-reported clinical encounters: Implications for cessation efforts

Preventive Medicine Reports
Introduction: Accelerating smoking cessation, particularly among young adults, is a national priority for decreasing tobacco-related disease. Healthcare providers play a critical role in delivering tobacco treatment interventions to this population. This
Melissa Mercincavage, Catherine Chen, Isabel Trenholm, Nishi J. Gonsalves, William J. Young, Michelle T. Bover Manderski, Manish S. Patel, Mary K. O’Connor, Daniel Gundersen, Cristine D. Delnevo, Michael B. Steinberg   +10 more
doaj   +1 more source

The impact of pharmacogenetic‐informed care on medication adherence and psychological factors associated with adherence: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Improvement in medication adherence is often proposed as a potential advantage of pharmacogenetic‐guided prescribing over a traditional one‐size‐fits‐all approach. This paper provides a review of the published literature and presents the findings of studies that measure adherence to medication as an outcome of pharmacogenetic‐informed care, or that ...
Lucy Galloway, Alison Wright, John Weinman   +2 more
wiley   +1 more source

Tobacco particulate matter is more potent than nicotine at upregulating nicotinic receptors on SH-SY5Y cells

, 2007
The effect of total particulate matter (TPM) from cigarette smoke on the expression and binding properties of nicotinic acetylcholine receptors (nAChRs) was investigated using a human neuroblastoma cell line (SH-SY5Y).
Fowles, Jefferson, H. Miller, John, Ambrose, Vikki, A. Lea, Rodney, J. Dickson, Stuart, Hampton, Scott, Truman, Penelope   +6 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Development of tobacco and nicotine policy : Proposals for action by the working group 2023

, 2023
On 7 February 2022, the Ministry of Social Affairs and Health appointed a working group tasked with making proposals for legislative amendments and other measures that support and promote the end of the use of tobacco and nicotine products by 2030.

core  

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system employing Escherichia coli cells expressing a nitrilase from Paraburkholderia
Jonathan Bassut, Emina Mehić, Luana Cuvillier, Carine Vergne‐Vaxelaire, Jean‐Louis Petit, Maïté Michaud, Zoé Anxionnaz‐Minvielle, Anne Zaparucha, Guillaume Nonglaton   +8 more
wiley   +1 more source

U.S. Physicians’ Views on E-Cigarette Risks and Benefits to Adults Who Smoke Versus Young People Who Do Not Smoke

AJPM Focus
Introduction: Emerging evidence suggests that E-cigarettes are likely less harmful than combustible cigarettes, presenting an opportunity for adults who smoke to quit or switch.
Monica Magalhaes, PhD, Michelle T. Bover Manderski, PhD, MPH, Michelle Jeong, PhD, William J. Young, PhD, Michael B. Steinberg, MD, MPH, Nir Eyal, DPhil   +5 more
doaj   +1 more source