Results 91 to 100 of about 173,010 (312)

Prolonging the Reduction of Nicotine Self-Administration in Rats by Coadministering Chronic Nicotine With Amitifadine, a Triple Monoamine Reuptake Inhibitor With CYP2B6 Inhibitory Actions.

, 2019
INTRODUCTION:Existing treatments can aid tobacco smoking cessation, but they have low efficacy. Because there is a network of neural systems involved in tobacco addiction, combination treatments may provide greater efficacy.
Levin, Edward D, Wells, Corinne, Lee, Michelle, Rezvani, Amir H, McKinney, Anthony A, Rose, Jed E, Slade, Susan   +6 more
core   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Immediate early gene expression in the mesopontine tegmentum and midbrain after acute or chronic nicotine administration

, 2008
The reinforcing properties of nicotine depend partly on cholinergic projections from the pedunculopontine tegmental (PPTg) and laterodorsal tegmental (LDTg) nuclei to midbrain dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars
Porter, Ailsa
core  

Rapid reduction versus abrupt quitting for smokers who want to stop soon: a randomised controlled non-inferiority trial

, 2009
Background: The standard way to stop smoking is to stop abruptly on a quit day with no prior reduction in consumption of cigarettes. Many smokers feel that reduction is natural and if reduction programmes were offered, many more might take up treatment ...
Lindson, N, Ingram, JT, Robert West, West, R, Susan Michie, Jennie Inglis, Ingram Jackie T, Jane Beach, Lindson, Nicola, Inglis, Jennie, Lindson Nicola, Aveyard Paul, West Robert, Michie, S, Aveyard, P, Michie, Susan, West, Robert, Paul Aveyard, Inglis, J, Beach Jane, Beach, Jane, Ingram, Jackie T., Ingram, Jackie, Ingram, Jackie T, Inglis Jennie, Nicola Lindson, Jackie T Ingram, Aveyard, Paul, Beach, J, Michie Susan   +29 more
core   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Protective Effect of Nicotine on Sepsis-Induced Oxidative Multiorgan Damage: Role of Neutrophils

, 2017
Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs ...
ÖZBEYLİ, DİLEK, YEGEN, BERRAK, ERCAN, FERİHA, ÖZDEMİR KUMRAL, ZARİFE NİGAR   +3 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Ameliorative Effect of Chronic Moderate Exercise in Smoke Exposed or Nicotine Applied Rats From Acute Stress

, 2015
Introduction: Physical activity has been found to be related with many health benefits. Our aim was to investigate the effect of chronic moderate exercise from acute stress on nicotine and cigarette smoke exposed rats.
AKAKIN, DİLEK, YARAT, AYŞEN, KASIMAY ÇAKIR, ÖZGÜR, KAYA, ÖZLEM TUĞÇE   +3 more
core   +1 more source

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, EarlyView.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

U.S. Physicians’ Views on E-Cigarette Risks and Benefits to Adults Who Smoke Versus Young People Who Do Not Smoke

AJPM Focus
Introduction: Emerging evidence suggests that E-cigarettes are likely less harmful than combustible cigarettes, presenting an opportunity for adults who smoke to quit or switch.
Monica Magalhaes, PhD, Michelle T. Bover Manderski, PhD, MPH, Michelle Jeong, PhD, William J. Young, PhD, Michael B. Steinberg, MD, MPH, Nir Eyal, DPhil   +5 more
doaj   +1 more source