Results 91 to 100 of about 303,294 (304)

Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice

Brain and Behavior, 2020
Objectives There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids.
Fernando B. deMoura, Jenny L. Wilkerson, Lance R. McMahon   +2 more
doaj   +1 more source

Definitions of community‐level approaches to address substance‐related harms and lessons learned: A systematic overview of reviews

American Journal of Community Psychology, EarlyView.
Abstract Community action focused on sociocultural and environmental influences to prevent alcohol and other drug (AOD) use and related harms is a global priority. Despite this recognition, understanding of effective community‐level approaches is limited.
Peter Gates, Andrea Zocco, Sara Farnbach
wiley   +1 more source

HPTLC assay of nicotine and cotinine in biological samples [PDF]

, 2018
This study presents the development of a simple high-performance thin layer chromatography (HPTLC) method for the determination of nicotine and its metabolite cotinine in human plasma and urine.
Baconi, Daniela Luiza, Balalau, Cristian, Ciobanu, Anne Marie, Constantin, Vlad D., Ples, Liana, Stan, Miriana, Vlasceanu, Ana Maria   +6 more
core   +1 more source

Neural signatures of cognitive flexibility and reward sensitivity following nicotinic receptor stimulation in dependent smokers : a randomized trial [PDF]

, 2017
IMPORTANCE Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid ...
Aronson, Sarah E., Lesage, Elise, Ross, Thomas J., Salmeron, Betty Jo, Stein, Elliot A., Sutherland, Matthew T.   +5 more
core   +2 more sources

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. [PDF]

, 2020
Rationale: Cigarette smoking is a well-established risk factor for myocardial infarction and sudden cardiac death. The deleterious effects are mainly due to nicotine, but the mechanisms involved and theranostics remain unclear.
Fu, Yingjie, Huang, Lei, Li, Yong, Liu, Bailin, Shao, Xuesi M, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +7 more
core  

Nicotine

, 2006
europepmc   +2 more sources

Drinking in the Dark: Voluntary Co-consumption of Nicotine and Alcohol for Binge-like Drinking Behavior in Mice [PDF]

, 2019
Alcohol and nicotine are two of the most commonly abused drugs across the United States. Given the high rates of comorbidity, it remains a pressing public health concern to determine how the two drugs interact within the CNS, and how this impacts ...
Benson, Katherine
core   +1 more source

Associations of demographic and tobacco use characteristics with young adults’ self-reported clinical encounters: Implications for cessation efforts

Preventive Medicine Reports
Introduction: Accelerating smoking cessation, particularly among young adults, is a national priority for decreasing tobacco-related disease. Healthcare providers play a critical role in delivering tobacco treatment interventions to this population. This
Melissa Mercincavage, Catherine Chen, Isabel Trenholm, Nishi J. Gonsalves, William J. Young, Michelle T. Bover Manderski, Manish S. Patel, Mary K. O’Connor, Daniel Gundersen, Cristine D. Delnevo, Michael B. Steinberg   +10 more
doaj   +1 more source

CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence

Scientifica, 2015
Each CYP2A6 gene variant metabolizes nicotine differently depending on its enzymatic activities. The normal nicotine metabolizer CYP2A6*1A is associated with high scores of nicotine dependence (5–10) on the Fagerström Test for Nicotine Dependence (FTND ...
Yawo Mawuli Akrodou
doaj   +1 more source