Results 21 to 30 of about 210,777 (258)

Cocreation of a conversational agent to help patients adhere to their varenicline treatment: A study protocol

Digital Health, 2023
Objective Varenicline is the most efficacious approved smoking cessation medication, making it one of the most cost-effective clinical interventions for reducing tobacco-related morbidity and mortality. Adhering to varenicline is strongly associated with
Nadia Minian, Kamna Mehra, Jonathan Rose, Scott Veldhuizen, Laurie Zawertailo, Matt Ratto, Julia Lecce, Peter Selby   +7 more
doaj   +1 more source

Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study

Frontiers in Neuroscience, 2023
Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component in both tobacco and e-cigarettes, can exist in two forms: nicotine-freebase (FBN ...
Pengfei Han, Pengfei Han, Pengfei Han, Pengfei Han, Pengfei Han, Xiaoyuan Jing, Shulei Han, Shulei Han, Shulei Han, Shulei Han, Xinsheng Wang, Qiannan Li, Qiannan Li, Qiannan Li, Qiannan Li, Yuan Zhang, Yuan Zhang, Yuan Zhang, Yuan Zhang, Pengpeng Yu, Pengpeng Yu, Pengpeng Yu, Pengpeng Yu, Xin-an Liu, Ping Wu, Huan Chen, Huan Chen, Huan Chen, Huan Chen, Hongwei Hou, Hongwei Hou, Hongwei Hou, Hongwei Hou, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu   +36 more
doaj   +1 more source

Stability Enhancement and Skin Permeation Application of Nicotine by Forming Inclusion Complex with β-Cyclodextrin and Methyl-β-Cyclodextrin

Scientia Pharmaceutica, 2021
Nicotine is widely used in pharmaceutical industries, especially for smoking cessation in the form of transdermal patches. Nicotine gel in the patches has limitations from nicotine instability and high volatility.
Sorrawee Chulurks, Kulpavee Jitapunkul, Sasimas Katanyutanon, Pisanu Toochinda, Luckhana Lawtrakul   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Rapid tobacco surveillance among young people in six states: Methods and findings from the Center for Rapid Surveillance of Tobacco Youth and Young Adult Cohort

Preventive Medicine Reports
Objective: The goal of this study is to describe the methods of the Rutgers Center for Rapid Surveillance of Tobacco Youth and Young Adult Cohort. Methods: Participants completed a multi-phase online screening process with 155 youth (ages 12–17) and 551 ...
Andrea C. Villanti, Patrick V. Barnwell, An Mei Chen, Caitlin Uriarte, Karolin Wadie, Mary Hrywna, Cristine D. Delnevo   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Sociodemographic differences in patterns of nicotine and cannabis vaping among US adults

Preventive Medicine Reports, 2022
Nicotine and cannabis vaping has increased over the past several years. While patterns of cigarette and cannabis co-use are well-documented, less is known about the intersection between nicotine and cannabis vaping, especially among adults.
Delvon T. Mattingly, Akash Patel, Jana L. Hirschtick, Nancy L. Fleischer   +3 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Trajectories of lifetime vaping in teens and young adults: latent transition analyses over one year

BMC Public Health
Background Despite the bidirectional relationship between initiation of cannabis and nicotine vaping, little is known about the patterns of vaping experimentation and progression among young people.
Allison M. Glasser, Marisa Tomaino, Caitlin Uriarte, Chelsea Carman, Maria Roemhildt, Rhonda Williams, Julia Chen-Sankey, Andrea C. Villanti   +7 more
doaj   +1 more source

Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial

Trials, 2020
Background Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive; as such, there is much interest in optimizing the effectiveness of existing treatments and ...
Laurie Zawertailo, Christian S. Hendershot, Rachel F. Tyndale, Bernard Le Foll, Andriy V. Samokhvalov, Kevin E. Thorpe, Andrew Pipe, Robert D. Reid, Peter Selby   +8 more
doaj   +1 more source