Results 31 to 40 of about 303,294 (304)
Comparative cytotoxicity study of nicotine and cotinine on MRC-5 cell line [PDF]
, 2018 Nicotine has several health hazards regarding carcinogenic potential. It also imparts increased risk for respiratory, cardiovascular, and gastrointestinal disorders.
Baconi, Daniela Luiza +4 more
core +4 more sources
Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions [PDF]
, 2003 Background - Antigen-presenting cells (APCs) such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation in the course of adaptive immunity.
Aicher, A +5 more
core +1 more source
Systematic Reviews, 2019 Background The lifetime risk of suicide in patients with substance use disorder is five to ten times the risk in the general population. Critically, up to 19% of patients continue to think about and attempt suicide even after accessing treatment ...
S. Espinet +10 more
doaj +1 more source
Scientia Pharmaceutica, 2021 Nicotine is widely used in pharmaceutical industries, especially for smoking cessation in the form of transdermal patches. Nicotine gel in the patches has limitations from nicotine instability and high volatility.
Sorrawee Chulurks +4 more
doaj +1 more source
Neuron, 2009 Both conscious and unconscious memory mechanisms contribute to the rewarding effects of nicotine and other drugs of abuse. In this issue of Neuron, Tang and Dani use in vivo measures of synaptic plasticity in freely moving mice to link nicotine-induced dopamine release in hippocampus to LTP induction and behavioral reinforcement.
openaire +2 more sources
Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment [PDF]
The Journal of Neuroscience, 1992 DBA mice were chronically treated with nicotine by continuous intravenous infusion of 4.0 mg/kg/hr for 10 d. Drug-treated mice were tolerant to the acute effects of nicotine on locomotor activity and body temperature. The effect of chronic treatment on the amount of L-3H- nicotine binding and RNA encoding for alpha 4, the most widely expressed ...
M J, Marks +6 more
openaire +2 more sources
Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)? [PDF]
, 2019 Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large ...
Alexescu, Teodora G +13 more
core +2 more sources
Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study [PDF]
, 2013 Aim To examine the relationship between a childhood diagnosis of attention deficit hyperactivity disorder (ADHD) with or without oppositional defiant disorder (ODD)/conduct disorder (CD) and the development of later alcohol/drug use disorder ...
Buitelaar, JK +8 more
core +3 more sources
Acute effects of nicotine on visual search tasks in young adult smokers [PDF]
, 2005 Rationale Nicotine is known to improve performance on tests involving sustained attention and recent research suggests that nicotine may also improve performance on tests involving the strategic allocation of attention and working memory.
A Miyake +45 more
core +2 more sources
Trials, 2020 Background Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive; as such, there is much interest in optimizing the effectiveness of existing treatments and ...
Laurie Zawertailo +8 more
doaj +1 more source