Results 51 to 60 of about 173,010 (312)

Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. [PDF]

, 2021
OBJECTIVES To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3'-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of ...
Jacob, Peyton, Dempsey, Delia A, Tyndale, Rachel F, Addo, Newton, Liakoni, Evangelia, Benowitz, Neal L   +5 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Dissolution Testing of Nicotine Release from OTDN Pouches: Product Characterization and Product-to-Product Comparison

Separations, 2021
In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new oral tobacco product category. They are available in a variety of flavors and do not contain cut or ground tobacco leaf.
Fadi Aldeek, Nicholas McCutcheon, Cameron Smith, John H. Miller, Timothy L. Danielson   +4 more
doaj   +1 more source

Nicotine Withdrawal [PDF]

, 2015
An aversive abstinence syndrome manifests 4-24 h following cessation of chronic use of nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off over the course of the following 3-4 weeks. While the severity of withdrawal symptoms is largely determined by how nicotine is consumed, certain short nucleotide polymorphisms ...
Ian, McLaughlin, John A, Dani, Mariella, De Biasi   +2 more
openaire   +2 more sources

Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors

Advanced Materials, EarlyView.
A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li, Di Shen, Ziyang Huang, Suppanat Puangpathumanond, Calvin Thenarianto, Yue Zhao, Jolly Madathiparambil Saju, Rajani Sarojam, Dongmei Zhou, Tedrick Thomas Salim Lew   +9 more
wiley   +1 more source

Association between exposure to digital alcohol marketing and alcohol use: a systematic review and meta-analysis

The Lancet Public Health
Summary: Background: Exposure to digital alcohol marketing content might be associated with pro-alcohol-related attitudes and behaviours, including the likelihood of initiating or sustaining the use of alcohol, especially among adolescents (aged
Scott I Donaldson, PhD, Alex M Russell, PhD, Kathryn La Capria, MPH, Amanda DeJesus, MA, Emily Wang, Jamil Fayad, Jon-Patrick Allem, PhD   +6 more
doaj   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

“We’re building the plane while we’re flying it”: perspectives on local cigar policy implementation from qualitative interviews with key personnel

Implementation Science Communications
Background Nearly 300 US municipalities have enacted policies regulating cigar pack size and price to reduce youth access to and use of inexpensive cigars.
Jessica King Jensen, Kathryn LaCapria, Stefanie Gratale, Myneka Macenat, Jeanne M. Ferrante, Alexandra McGarry Williams, Hassiet Asberom, Cristine D. Delnevo, Sunday Azagba   +8 more
doaj   +1 more source

Nicotine Addiction and Impulsive Behaviour: Disentangling the Relationship [PDF]

, 2007
Drug addiction can now be considered a global epidemic with considerable psychological, physical, social and economicc osts. Substantial research remains focused upon furthering our understating of the disorder, for which current treatments are limited ...
Kolokotroni, Katerina Zoe
core  

Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking [PDF]

, 2011
Background Smokers need effective support to maximise the chances of successful quit attempts. Current smoking cessation medications, such as nicotine replacement therapy (NRT), bupropion, nortriptyline or varenicline, have been shown to be effective in ...
Hayden McRobbie, Nosa, Vili, Nosa, V, Walker, N, Glover, M, Howe Colin, Joanne Barnes, Bullen, C, Glover Marewa, McRobbie Hayden, Jonathan Williman, McRobbie, H, Barnes, J, Howe, C, Walker Natalie, Colin Howe, Williman, J, Bullen, Christopher, Parag, Varsha, Bullen Chris, Reon Veale, Greenaway, Natalie, Varsha Parag, Glover, Marewa, Natalie Walker, Parag Varsha, Veale Reon, Marewa Glover, Barnes, Joanne, Vili Nosa, Veale, R, Parag, V, Williman Jonathan, Williman, Jonathan, Nosa Vili, Chris Bullen, Barnes Joanne   +36 more
core   +1 more source