Results 351 to 360 of about 465,225 (381)
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British Journal of Addiction, 1989
SummaryIn recent years progress in basic neuropsychopharmacology and clinical addiction research have allowed the conclusion that tobacco smoking essentially represents an addiction to nicotine. Parallel to this work, experimental research in biochemistry, physiology and pharmacology has provided detailed descriptions of the structure and function of ...
J. Grenhoff, Torgny H. Svensson
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SummaryIn recent years progress in basic neuropsychopharmacology and clinical addiction research have allowed the conclusion that tobacco smoking essentially represents an addiction to nicotine. Parallel to this work, experimental research in biochemistry, physiology and pharmacology has provided detailed descriptions of the structure and function of ...
J. Grenhoff, Torgny H. Svensson
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Review: Nicotinic receptors and stages of nicotine dependence
Journal of Psychopharmacology, 2009Smoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. Consequently, there have been extensive investigations into the neuroadaptations that occur as nicotine dependence develops, where numerous neurological systems have been implicated. The focus of this review was
Rodney A. Lea +3 more
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Science, 1959
Radioactive nicotine was synthesized by Nicotiana rustica L. which was fed sodium acetate-1-C 14 , sodium acetate-2-C 14 , sodium pyruvate-1-C 14 , or sodium pyruvate-3-C 14 .
Richard U. Byerrum, Thomas Griffith
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Radioactive nicotine was synthesized by Nicotiana rustica L. which was fed sodium acetate-1-C 14 , sodium acetate-2-C 14 , sodium pyruvate-1-C 14 , or sodium pyruvate-3-C 14 .
Richard U. Byerrum, Thomas Griffith
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Nicotine metabolism variability and nicotine addiction
Nicotine & Tobacco Research, 1999Individual variation in nicotine metabolism may play a role in a person's level of smoking, as well as in the transition from initiation to maintenance of a smoking behavior pattern. Since there is a paucity of research on nicotine metabolism in youth that smoke, a brief review of salient aspects of nicotine metabolism in adults provides a basis from ...
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Biochemical and Biophysical Research Communications, 1975
Abstract A sensitive and specific radioimmunoassay of nicotine was developed using antisera raised against 6-(p-aminobenzamido) nicotine coupled to bovine serum albumin. Inhibition studies with various nicotine analogues revealed that the antisera are highly specific for both the N-methylpyrrolidine ring and the pyridine ring of nicotine, and ...
Tatsuya Ishiguro +6 more
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Abstract A sensitive and specific radioimmunoassay of nicotine was developed using antisera raised against 6-(p-aminobenzamido) nicotine coupled to bovine serum albumin. Inhibition studies with various nicotine analogues revealed that the antisera are highly specific for both the N-methylpyrrolidine ring and the pyridine ring of nicotine, and ...
Tatsuya Ishiguro +6 more
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Journal of Agricultural and Food Chemistry, 1999
Thermal transfer to nicotine in the gas phase from neat nicotine, from various nicotine carboxylic acid salts, and from endogenous nicotine in Burley, Bright, and Oriental tobacco samples has been examined by thermogravimetric/differential thermal analysis/mass spectroscopy and evolved gas analysis.
J B Paine rd +3 more
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Thermal transfer to nicotine in the gas phase from neat nicotine, from various nicotine carboxylic acid salts, and from endogenous nicotine in Burley, Bright, and Oriental tobacco samples has been examined by thermogravimetric/differential thermal analysis/mass spectroscopy and evolved gas analysis.
J B Paine rd +3 more
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Apoptosis, 2007
Cigarette smoking is associated with a plethora of different diseases. Nicotine is the addictive component of cigarette but also acts onto cells of the non-neuronal system, including immune effector cells. Although nicotine itself is usually not referred to as a carcinogen, there is ongoing debate whether nicotine functions as a 'tumor enhancer.' By ...
Kaj Albermann +2 more
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Cigarette smoking is associated with a plethora of different diseases. Nicotine is the addictive component of cigarette but also acts onto cells of the non-neuronal system, including immune effector cells. Although nicotine itself is usually not referred to as a carcinogen, there is ongoing debate whether nicotine functions as a 'tumor enhancer.' By ...
Kaj Albermann +2 more
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Nature, 1953
FOLLOWING the demonstration that the amino-acid tryptophane can readily be converted by barley plants into the alkaloid gramine1, the study of the biogenesis of alkaloids carried on here has included investigations into the possibility that nicotine may arise from tryptophane in a manner similar to the formation of nicotinic acid in animals and ...
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FOLLOWING the demonstration that the amino-acid tryptophane can readily be converted by barley plants into the alkaloid gramine1, the study of the biogenesis of alkaloids carried on here has included investigations into the possibility that nicotine may arise from tryptophane in a manner similar to the formation of nicotinic acid in animals and ...
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Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders
Current Topics in Medicinal Chemistry, 2004Advances in the understanding of the neurobiology of the nicotinic receptor have started to be matched by an appreciation of the potential role of these receptors in a variety of neuropsychiatric disorders. While alterations in nicotinic receptor number and/or function have been associated with such conditions as Alzheimer's disease for several years ...
Alexandra Potter +2 more
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1981
Cigarette smoking is one of the most persistent habits known to man; for many years, he has been possessed by the bizarre but irresistible urge to inhale the smoke produced by burning the dried and shredded leaves of Nicotiana tabacum. The alternative methods of administration, sniffing and chewing, lost favor with the introduction of cheap cigarettes ...
R. Kumar, M. Lader
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Cigarette smoking is one of the most persistent habits known to man; for many years, he has been possessed by the bizarre but irresistible urge to inhale the smoke produced by burning the dried and shredded leaves of Nicotiana tabacum. The alternative methods of administration, sniffing and chewing, lost favor with the introduction of cheap cigarettes ...
R. Kumar, M. Lader
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