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Pharmacogenetics and Nicotine Addiction Treatment
Pharmacogenomics, 2005This review focuses on the current status of, and future directions for, pharmacogenetic research on nicotine dependence and smoking cessation treatment. Pharmacological treatment involving nicotine replacement therapy and bupropion for nicotine addiction and smoking cessation has been shown to be efficacious when provided in combination with ...
Munafo, MR +4 more
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Cellular mechanisms of nicotine addiction
Pharmacology Biochemistry and Behavior, 2001In developed countries, tobacco use is estimated to be the largest single cause of premature death [Lancet 339 (1992) 1268]. Nicotine is the main addictive component of tobacco that motivates continued use despite the harmful effects. Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the mammalian central nervous system (CNS),
J A, Dani, M, De Biasi
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Neuronal networks of nicotine addiction
The International Journal of Biochemistry & Cell Biology, 2010Nicotine is the main psychoactive substance present in tobacco, targeting neuronal nicotinic acetylcholine receptors. The main effects of nicotine associated with smoking are nicotinic receptor activation, desensitization, and upregulation, with the subsequent modulation of the mesocorticolimbic dopaminergic system.
Marcelo O, Ortells, Hugo R, Arias
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Hawaii medical journal, 1990
Addiction to nicotine is the most common serious condition in medicine today. This chemical dependency has produced the largest epidemic of disease in this century, an epidemic that is beginning to wane in the United States but which is accelerating in the Third World.
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Addiction to nicotine is the most common serious condition in medicine today. This chemical dependency has produced the largest epidemic of disease in this century, an epidemic that is beginning to wane in the United States but which is accelerating in the Third World.
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JAMA, 1995
Objective. —To learn how nicotine has been regarded by a major tobacco company. Data Sources. —Documents from Brown and Williamson Tobacco Corporation (BW274:225-233)
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Objective. —To learn how nicotine has been regarded by a major tobacco company. Data Sources. —Documents from Brown and Williamson Tobacco Corporation (BW274:225-233)
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Modeling Nicotine Addiction in Rats
2011Among the human population, 15% of drug users develop a pathological drug addiction. This figure increases substantially with nicotine, whereby more than 30% of those who try smoking develop a nicotine addiction. Drug addiction is characterized by compulsive drug-seeking and drug-taking behaviors (craving), and loss of control over intake despite ...
Stephanie, Caille +3 more
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Medicinski arhiv, 2002
According to the WHO reports from 1997, Bosnia and Herzegovina takes a disgraceful first place in smoking prevalence in Europe. 53% of smokers over 15, then 22% of women, 67% of men are percentages that are not achieved by countries at a much lower development level than B&H. The mortality rate of men (aged 35-64) as a result of tobacco varies from 11%
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According to the WHO reports from 1997, Bosnia and Herzegovina takes a disgraceful first place in smoking prevalence in Europe. 53% of smokers over 15, then 22% of women, 67% of men are percentages that are not achieved by countries at a much lower development level than B&H. The mortality rate of men (aged 35-64) as a result of tobacco varies from 11%
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly