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Neurobiology of Nicotine Dependence [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any other substance. Preclinical research in animal models of the various aspects of nicotine dependence suggests a critical role of glutamate, γ-aminobutyric acid (GABA ...
Athina Márkou
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Anhedonia in Nicotine Dependence
2022Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking abstinence leads to anhedonic states in some individuals and situations, and nicotine administration reduces anhedonic states.
David G, Gilbert, Bryant M, Stone
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Nicotine Dependence and Schizophrenia
Psychiatric Services, 1994The following recommendations are offered for evaluating and treating nicotine dependence among patients with schizophrenia. Assessment of patients's nicotine usage should be a routine part of psychiatric evaluation and treatment planning. Heavy smokers should be closely evaluated for other substance abuse.
Ziedonis, Douglas M. +3 more
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Life Sciences, 1989
Health hazards associated with nicotine and tobacco use are well known. A contributing factor, the dependence producing potential of this drug, has become widely accepted. However, there are only a few human and animal studies that provide objective measures of the behavioral consequences of nicotine abstinence.
M E, Carroll +3 more
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Health hazards associated with nicotine and tobacco use are well known. A contributing factor, the dependence producing potential of this drug, has become widely accepted. However, there are only a few human and animal studies that provide objective measures of the behavioral consequences of nicotine abstinence.
M E, Carroll +3 more
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The American Journal of the Medical Sciences, 2003
This article reviews the biology of nicotine addiction and the most effective treatments for nicotine dependence. Nicotine elevates dopamine levels in the brain, which is associated with drug reinforcement and dependence. Nicotine abuse leads to nicotine dependence.
Elbert D, Glover +2 more
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This article reviews the biology of nicotine addiction and the most effective treatments for nicotine dependence. Nicotine elevates dopamine levels in the brain, which is associated with drug reinforcement and dependence. Nicotine abuse leads to nicotine dependence.
Elbert D, Glover +2 more
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The Nicotine Dependence Syndrome Scale: A multidimensional measure of nicotine dependence
Nicotine & Tobacco Research, 2004We report the development of a new multidimensional questionnaire to measure nicotine dependence, based on Edwards's syndromal conceptualization of dependence. We present three studies. In study 1, we administered the Nicotine Dependence Syndrome Scale (NDSS) to 317 smokers in a smoking cessation study. Factor analysis of the NDSS revealed five factors:
Saul, Shiffman +2 more
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Journal of Addictive Diseases, 1992
Nicotine dependence has been clearly documented as an addiction to nicotine. The development of tolerance and dependence to nicotine has been documented as well in studies in animals and humans. The morbidity and mortality from nicotine dependence continues to be widespread and significant in spite of some reduction in the prevalence of use.
N S, Miller, J A, Cocores
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Nicotine dependence has been clearly documented as an addiction to nicotine. The development of tolerance and dependence to nicotine has been documented as well in studies in animals and humans. The morbidity and mortality from nicotine dependence continues to be widespread and significant in spite of some reduction in the prevalence of use.
N S, Miller, J A, Cocores
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2017
Nicotine is a psychoactive drug with effects that reinforce tobacco use despite known adverse health consequences. Nicotine dependence can be effectively treated. Family physicians are in an excellent position to promote both smoking cessation and smoking prevention.
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Nicotine is a psychoactive drug with effects that reinforce tobacco use despite known adverse health consequences. Nicotine dependence can be effectively treated. Family physicians are in an excellent position to promote both smoking cessation and smoking prevention.
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Pharmacotherapy of nicotine dependence
Int. Journal of Clinical Pharmacology and Therapeutics, 2000Withdrawal treatment of cigarette smokers is a task of the utmost urgency in view of the consequences for national health programs and legislative policies of the high morbidity and mortality rates caused by smoking. Smokers need medical consultation in addition to drug-based treatment, but this results in self-willed quitting of the smoking habit in a
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