Results 51 to 60 of about 3,355,558 (275)

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

open access: yesAdvanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang   +15 more
wiley   +1 more source

Effectiveness of auricular acupuncture combined with nicotine replacement therapy for smoking cessation

open access: yes, 2018
Introduction The aim of this study was to establish if the auricular acupuncture treatment can play a complementary role in enhancing the smoking cessation rate of the smokers receiving conventional therapy, such as NRT and behavioral counseling ...
Nam gyu Kang, Hyuk Huh, Sangho Hyun
core   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

open access: yesAdvanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo   +12 more
wiley   +1 more source

Building families—Implementing balanced sexual and reproductive health

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu   +9 more
wiley   +2 more sources

GP prescribing of nicotine replacement and bupropion to aid smoking cessation in England and Wales [PDF]

open access: yes, 2004
Aims Prescribing nicotine replacement therapy (NRT) or bupropion for smoking cessation is of considerable importance to public health but little is known about prescribing practices.
McEwen, A, Owen, L, West, R
core  

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source

ANTI-NICOTINE VACCINES: NEW PERSPECTIVE FOR SMOKERS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

open access: yesBerkala Kedokteran, 2017
: Smoking and Chronic Obstructive Pulmonary Disease (COPD) become a global problem in the world. The increasing number of smokers in the world also led to significantly increased morbidity and mortality due to COPD.
Marsheilla Riska
doaj   +1 more source

The safety and efficacy of nicotine replacement therapy for smoking cessation: A protocol for systematic review update and meta-analysis

open access: yes, 2022
Benefits and harms of nicotine replacement therapy in smoking cessation have not been adequately assessed. This systematic review will evaluate and summarize available evidence addressing benefits and harms of nicotine replacement therapy.
정현 김
core   +1 more source

Transosseous Equivalent Meniscus Allograft Transplantation Using an All‐Suture‐Based Anchor Technique

open access: yesArthroscopy Techniques, EarlyView.
Abstract Meniscal allograft transplantation is a surgical solution for symptomatic meniscal deficiency aimed at restoring native knee biomechanics and tibiofemoral contact pressures with the goal of slowing the progression of osteoarthritis. Anatomic fixation of the meniscal root is essential to a successful outcome as this normalizes native ...
Megan E. Barney   +5 more
wiley   +1 more source

Providing Nicotine Replacement Therapy in Focus Groups [PDF]

open access: yesNicotine & Tobacco Research, 2017
In many research studies, tobacco users are asked to forgo tobacco during study appointments to avoid interrupting study sessions with breaks or disrupting research flow and efficiency. Although onset of withdrawal varies according to levels of nicotine dependence, symptoms commonly begin within 30 minutes of abstinence.
Ellen E, Jones   +2 more
openaire   +2 more sources

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