Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens [PDF]
Frontiers in Pharmacology, 2023 With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts.
Xiaonan Li +9 more
doaj +6 more sources
Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study [PDF]
Frontiers in Neuroscience, 2023 Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component in both tobacco and e-cigarettes, can exist in two forms: nicotine-freebase (FBN ...
Pengfei Han +36 more
doaj +6 more sources
Characterization of Nicotine Salts in 23 Electronic Cigarette Refill Liquids. [PDF]
Nicotine Tob Res, 2020 Abstract Introduction Many electronic cigarette manufacturers have begun offering liquids containing “nicotine salts,” which are formed when an acid is mixed in a solution with free-base nicotine. Type of salt could play a significant role in the abuse liability of electronic cigarette liquids.
Harvanko AM +3 more
europepmc +8 more sources
In vitro toxicological evaluation of aerosols generated by a 4th generation vaping device using nicotine salts in an air-liquid interface system [PDF]
Respiratory ResearchBackground Electronic cigarettes (EC) have gained popularity, especially among young people, with the introduction of fourth-generation devices based on e-liquids containing nicotine salts that promise a smoother vaping experience than freebase nicotine.
Clément Mercier +3 more
doaj +4 more sources
Comprehensive Dutch market data analysis shows that e-liquids with nicotine salts have both higher nicotine and flavour concentrations than those with free-base nicotine. [PDF]
Tob Control, 2023 ObjectivesRecent years have seen an increase in e-liquids containing nicotine salts. Nicotine salts are less harsh and bitter than free-base nicotine and therefore can facilitate inhalation. Because inhalation-facilitating ingredients are banned in the European Union, we assessed the occurrence and characteristics of nicotine salt-containing e-liquids ...
Pennings JLA +5 more
europepmc +6 more sources
Thermal properties and kinetic analysis of pyrolysis products of nicotine salts from e-cigarettes using pyrolysis-gas chromatography/mass spectrometry [PDF]
Frontiers in Environmental Science, 2023 Volatile organic chemicals (VOCs) released from e-cigarettes are a special source of air pollutants. In this work, we investigated the VOCs released from six nicotine salts (namely, nicotine benzoate, nicotine tartrate, nicotine citrate, nicotine malate,
Ji Yang +6 more
doaj +2 more sources
Drug Testing and Analysis, 2022 AbstractNicotine lactate, nicotine tartrate, nicotine benzoate, and freebase nicotine (FBN) are four forms of nicotine salt systems that are present in tobacco products. However, few in vivo studies have compared their pharmacological (pK) efficacies, which are important for understanding their roles in the addiction and abuse of tobacco and nicotine ...
Shulei Han +13 more
openaire +3 more sources
Thermochemical Properties of Nicotine Salts [PDF]
Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2001 Abstract The thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) results presented in this report clearly show that the thermal stability and the endothermic peak nicotine release temperatures are different for different nicotine salts and these temperatures appear to be linked to the general microstructural ...
DM Riggs, TA Perfetti
openaire +2 more sources
The Transfer of Nicotine from Nicotine Salts to Mainstream Smoke [PDF]
Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2000 Abstract Transfer of nicotine to mainstream smoke was measured for Reference cigarettes made with the addition of 20 -40 mg of seven different nicotine salts, d- and l-nicotine and N’-formylnornicotine. Regression analysis of the nicotine yields from these cigarettes as a function of the nicotine content of the tobacco rods indicated an ...
TA Perfetti +6 more
openaire +2 more sources
Crystal structures and hydrogen bonding in the proton-transfer salts of nicotine with 3,5-dinitrosalicylic acid and 5-sulfosalicylic acid [PDF]
Acta Crystallographica Section E, 2014 The structures of the 1:1 anhydrous salts of nicotine (NIC) with 3,5-dinitrosalicylic acid (DNSA) and 5-sulfosalicylic acid (5-SSA), namely (1R,2S)-1-methyl-2-(pyridin-3-yl)-1H-pyrrolidin-1-ium 2-carboxy-4,6-dinitrophenolate, C10H15N2+·C7H3N2O7−, (I ...
Graham Smith, Urs D. Wermuth
doaj +4 more sources