Results 61 to 70 of about 12,727 (207)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

LOUIS HENRI FREDERIC MELSENS Nicotine, potassium iodide, and sulfur compounds

Revista CENIC Ciencias Químicas, 2020
Louis Henri Frédéric Melsens (1814-1886) was a Belgian chemist, student of Dumas and Liebig, who showed the possibility of chlorinating an organic compound by hydrogen substitution; separated nicotine, determined its formula, and proved it was a powerful
Jaime Wisniak
doaj  

Is Addiction Research Addicted to Artificial Intelligence? Mapping the Intersection of Artificial Intelligence, Substance Use and Mental Health Through a Bibliometric Analysis

Drug and Alcohol Review, EarlyView.
ABSTRACT Issues From extracting insights from large‐scale, multimodal data to prevention and support, there is growing interest in the applications and implications of recent advances in Artificial Intelligence (AI) within the fields of addiction, substance use and mental health, which we refer to as ASUM.
Loïs Vanhée, Simone Scarpa
wiley   +1 more source

Protracted treatment with MDMA induces heteromeric nicotinic receptor up-regulation in rat brain: an autoradiography study. [PDF]

, 2014
Previous studies indicate that 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy) can induce heteromeric nicotinic acetylcholine receptor (nAChR, mainly of α4β2 subtype) up-regulation.
Albuquerque, Andrés Ciudad-Roberts, Awtry, Battaglia, Biezonski, Broening, Camarasa, Capela, Cheramy, Chipana, Ciudad-Roberts, Cobb, Cumming, David Pubill, Elena Escubedo, Fitzgerald, Gaimarri, Garcia-Rates, Garcia-Rates, Gopalakrishnan, Gordon, Gotti, Govind, Grady, Green, Ikemoto, Jones, Jorge Camarasa, Kuryatov, Lester, Levin, Malberg, Mameli-Engvall, Marchi, Martin, Mudo, Mugnaini, Nguyen, O'Shea, Paxinos, Peng, Picciotto, Pubill, Pubill, Pubill, Reuben, Ripoll, Sallette, Schwartz, Srinivasan, Strome, Tribollet, Vallejo, Wesson, Whiteaker, Wonnacott, Yamamoto   +56 more
core   +2 more sources

Effects of an Isoquinoline Alkaloids Blend on the Expression of Genes Relevant for Antioxidant Capacity, Barrier Integrity and Inflammation Along the Broiler Gut

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Intensive broiler production may lead to perturbations of gut function and health. The maintenance of intestinal homeostasis in broilers through the use of dietary phytogenic components such as isoquinoline alkaloids (IQs) is an emerging topic of scientific investigations.
Vasileios V. Paraskeuas, Ioannis Brouklogiannis, Anja Pastor, Konstantinos C. Mountzouris   +3 more
wiley   +1 more source

The pH Dependent Interaction between Nicotine and Simulated Pulmonary Surfactant Monolayers with Associated Molecular Modelling [PDF]

, 2017
Pulmonary surfactant is an endogenous material that lines and stabilises the alveolar air-liquid interface. Respiratory mechanics can be compromised by exposure to environmental toxins such as cigarette vapour, which contains nicotine. This study aims to
Akella, Attwood, Behroozi, Bringezu, Bringezu, Burgermeister, Clark, Davies, Davies, Davies, DeRuiter, Ding, Duncan, Elmore, Fleming, Grancelli, Graton, Graton, Hall, Hariharan, Hunter, Jha, Khattari, Lucero, Mascal, Matti, Miñones, Notter, Notter, Omega, Pi, Putman, Quinn, Roothaan, Ryu, Scott, Shah, Silva, Stenger, Subramaniam, Takamoto, Veldhuizen, Wiedmann, Yu, Zasadzinski, Zhao   +45 more
core   +2 more sources

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. [PDF]

, 2018
Tobacco use disorder is the leading cause of disease and preventable death worldwide, but current medications that are based on pharmacodynamics have low efficacy.
George, Olivier, Janda, Kim D, Kallupi, Marsida, Xue, Song, Zhou, Bin   +4 more
core   +1 more source

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]

, 2019
copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria, Chilcott, Robert, Corazza, Ornella, Corkery, John, Guirguis, Amira, Marrinan, Shanna, Martinotti, Giovanni, Zloh, Mire   +7 more
core   +3 more sources

Geographic provenance and environmental growing conditions as factors influencing phytochemical composition of Arabica green coffee beans

Plant Biology, EarlyView.
Growth environment strongly influences green coffee bean biochemistry, linking phytochemical composition to adaptation under abiotic stress. Abstract This study explores how bioactive compounds in green coffee beans (Coffea arabica L.) vary across different geographic regions, addressing the key question of how environmental factors shape coffee ...
I. Pettazzoni, G. Benati, S. Monari, E. De Angelis, L. Navarini, M. Ferri, A. Tassoni   +6 more
wiley   +1 more source