Results 111 to 120 of about 329,742 (333)

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

open access: yes, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside   +5 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

Frequent occurrence of nicotinic acetylcholine receptors in GABAergic neurons of the chick visual system

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Double-labeling immunohistochemical methods were used to investigate the occurrence of the alpha8 and alpha5 nicotinic receptor subunits in presumptive GABAergic neurons of the chick nervous system.
A.S. Torrão, L.R.G. Britto
doaj   +1 more source

Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques [PDF]

open access: yes, 1985
Voltage-jump and light-flash experiments have been performed on isolated Electrophorus electroplaques exposed simultaneously to nicotinic agonists and to the photoisomerizable compound 2,2'-bis-[α-(trimethylammonium)methyl]-azobenzene (2BQ).
Erlanger, Bernard F.   +3 more
core   +1 more source

Translational Research in Nicotine Addiction [PDF]

open access: bronze, 2020
Miranda Fisher   +3 more
openalex   +1 more source

Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Nicotine has been associated with cognitive functions such as memory and attention, with serum neurofilament light chain (sNfL) as a biomarker for neurological diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS).
Qianqian Ji   +5 more
wiley   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

open access: yesChemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju   +4 more
wiley   +1 more source

In silico prediction of some pharmacokinetic, safety, biological activity and molecular docking studies of 1-piperazine indole hybrid with nicotinic amide and nicotinic acid and their analogues

open access: yesSAGE Open Medicine
Background: In silico predictions are now being utilized in drug discovery and design to assess the physicochemical, pharmacokinetics, and safety properties of compounds at the beginning of the drug discovery process.
Melese Legesse Mitku   +7 more
doaj   +1 more source

EFFECT OF NICOTINIC ACID SUPPLEMENTATION ON PRODUCTION PERFORMANCE OF LACTATING COWS [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2008
The effect of dietary supple-mentation of nicotinic acid on milk yield and milk fat percentage was studied in twelve lactating cows allotted at random to treatments T1 and T2.
Renjith Gopal   +4 more
doaj  

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