Results 131 to 140 of about 329,742 (333)

Gene variance in the nicotinic receptor cluster (CHRNA5‐CHRNA3‐CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers [PDF]

, 2015
Sara Halldén, Magnus Sjögren, Bo Hedblad, Gunnar Engström, Viktor Hamrefors, Jonas Manjer, Olle Melander   +6 more
openalex   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats [PDF]

, 2016
Kalyan N. Rao, Alena M. Sentir, Eric A. Engleman, Richard L. Bell, Leslie A. Hulvershorn, Alan Breier, R. Andrew Chambers   +6 more
openalex   +1 more source

Dietary‐Driven Gene Expansion

Clinical Pharmacology &Therapeutics, EarlyView.
Gene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Magnus Ingelman‐Sundberg
wiley   +1 more source

Low-temperature (< 200 °C) degradation of electronic nicotine delivery system liquids generates toxic aldehydes [PDF]

, 2021
Nicholas R. Jaegers, Wenda Hu, Thomas J. Weber, Jian Zhi Hu   +3 more
openalex   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population

European Journal of Heart Failure, EarlyView.
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.
Yvonne Huber, Lea Hofmann, Jürgen H. Prochaska, Thomas Koeck, Julian Chalabi, Norbert Pfeiffer, Manfred Beutel, Konstantin Strauch, Karl J. Lackner, Oliver Tüscher, Thomas Münzel, Matthias M. Weber, Julia Weinmann‐Menke, Philipp Wild, Peter R. Galle, Jörn M. Schattenberg   +15 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Nicotine Attenuates the Ventilatory Response to Hypoxia in the Developing Lamb [PDF]

, 1995
J Milerad, Hans Larsson, Jing Lin, Håkan Sundell   +3 more
openalex   +1 more source