Results 141 to 150 of about 75,040 (266)

Targeted Mutations Activate Allosteric Modulation of α5-Containing Nicotinic Acetylcholine Receptors. [PDF]

ACS Chem Neurosci
Marotta CB, Lester HA, Dougherty DA.
europepmc   +1 more source

Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study

Med Research, EarlyView.
This study examined the relative contributions of modifiable risk factors to cardiovascular diseases in adults with hypertension. More favorable risk factor profiles were consistently associated with lower risks across all outcomes. Beyond blood pressure, nicotine exposure showed comparatively larger population attributable fractions.
Shengtao Wei, Dashan Zheng, Lan Chen, Zitong Zhuang, Zihan Lin, Junguo Zhang, Peng Hu, Zijun Yang, Zhen‐He Huang, Bing Zhang, Hualiang Lin   +10 more
wiley   +1 more source

Receptor architecture of the macaque lateral geniculate nucleus. [PDF]

Brain Struct Funct
Saito M, Rapan L, Niu M, Zhao L, Tsujimura SI, Takemura H, Palomero-Gallagher N.   +6 more
europepmc   +1 more source

Associations Between Cumulative Head Trauma and Self‐Reported Parkinsonism and Parkinson's Disease in Former Soccer Players

Movement Disorders, EarlyView.
Abstract Background Cumulative head trauma, encompassing repetitive head impacts (RHI) and traumatic brain injury (TBI), has been associated with later‐life neurodegenerative disease. Studies on parkinsonism/Parkinson's disease (PD) have evaluated RHI and TBI in isolation, yielding mixed results.
Annalise E. Miner, Matthew J. Kmiecik, Niharika Namburi, Nathaniel Dunckley, Charles H. Adler, Erika D. Driver‐Dunckley, Christopher J. Nowinski, Joshua Gottesman, Yorghos Tripodis, Robert A. Stern, Ann C. McKee, Thor D. Stein, Jesse Mez, Farren B.S. Briggs, Michael L. Alosco   +14 more
wiley   +1 more source

Biochemical Alterations Related to Vascular Injury in Smokers: Evidence from Nitric Oxide, Malondialdehyde, Nicotinic Acetylcholine Receptors, and Cotinine. [PDF]

Vasc Health Risk Manag
Kumboyono K, Chomsy IN, Tjahjono CT, Kumala YR, Wihastuti TA.   +4 more
europepmc   +1 more source

Impact of Life‐Context Factors on Chronic Rhinosinusitis 22‐Item Sinonasal Outcomes Test: Systematic Review + Meta‐Analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Chronic rhinosinusitis (CRS) affects all sociodemographic groups. While studies have explored social determinants of health (SDOH), sociodemographics, and health behaviors, their specific effects on CRS outcomes are unclear, making tailored care difficult.
Kassandra M. Jade, George A. Scangas, Victoria S. Lee, Li‐Xing Man, Edward D. McCoul, Gabriela Guevara, Anahita Nourmahnad, John M. Reynolds, Corinna G. Levine   +8 more
wiley   +1 more source

Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss. [PDF]

Int J Mol Sci
Oman J, Sapkota P, Mateen S, Schulte M, Pashikanti S.   +4 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Correction: Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. [PDF]

Sci Rep
Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ.   +11 more
europepmc   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source