Results 281 to 290 of about 331,963 (334)
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Nicotine regulates α7 nicotinic receptor subunit mRNA: implications for nicotine dependence
Neuroreport, 2001Recent evidence suggests that alpha7 subunit-containing nicotinic receptors (nAChRs) within the ventral tegmental area (VTA) are involved in the processes underlying nicotine tolerance and withdrawal. The current study used in situ hybridization histochemistry with multiple radiolabelled probes to amplify mRNA signal, to examine the distribution of ...
R E, Ryan, R E, Loiacono
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2017
Nicotine is a psychoactive drug with effects that reinforce tobacco use despite known adverse health consequences. Nicotine dependence can be effectively treated. Family physicians are in an excellent position to promote both smoking cessation and smoking prevention.
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Nicotine is a psychoactive drug with effects that reinforce tobacco use despite known adverse health consequences. Nicotine dependence can be effectively treated. Family physicians are in an excellent position to promote both smoking cessation and smoking prevention.
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Nicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders
Archives of Medical Research, 2000Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-gated cation channels with diverse structures and properties. In contrast to the muscular nAChRs, the physiological functions of neuronal nAChRs are not well defined to date.
S, Mihailescu, R, Drucker-Colín
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SMOKING, NICOTINE, NICOTINE REPLACEMENT, AND CARDIOVASCULAR DISEASE
American Journal of Therapeutics, 1996Cigarette smoking is a major risk factor for the development of coronary artery disease and its complications. Nicotine is one of the major substances that contributes to the pharmacologic activity of cigarette smoke, its toxicity, as well as its addictive nature.
Anjum, Ismail +2 more
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Passive immunization against nicotine attenuates nicotine discrimination
Life Sciences, 2002Ten rats were trained in a two lever operant chamber to press different levers after a nicotine injection (0.14 mg/kg s.c.) or a saline injection on an FR10 schedule. The rats were then injected i.p. with either 150 mg nicotine-specific IgG or the same amount of control IgG from non-immunized rabbits.
David H, Malin +10 more
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Nicotine metabolism variability and nicotine addiction
Nicotine & Tobacco Research, 1999Individual variation in nicotine metabolism may play a role in a person's level of smoking, as well as in the transition from initiation to maintenance of a smoking behavior pattern. Since there is a paucity of research on nicotine metabolism in youth that smoke, a brief review of salient aspects of nicotine metabolism in adults provides a basis from ...
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Nicotine and Non-nicotine Smoking Cessation Pharmacotherapies
Cardiology in Review, 2006Cigarette smoking remains an important risk factor for premature cardiovascular disease and its complications. There are clear benefits of cigarette smoking cessation on the rate of clinical outcomes, and in addition to behavioral therapies, various pharmacologic strategies have been developed to help achieve this goal.
William H, Frishman +3 more
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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Nature, 2002Hong Wang +12 more
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Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Journal of Molecular Biology, 2005N. Unwin
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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
Nature, 2001Katjua Brejc +6 more
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