Results 191 to 200 of about 79,918 (320)

The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience

Aging Cell, Volume 25, Issue 1, January 2026.
Memantine, an NMDA receptor antagonist, extends lifespan and enhances stress resilience in C. elegans through caloric restriction–like metabolic adaptations, including reduced oxidative stress and increased fatty acid β‐oxidation, revealing a conserved mechanism linking glutamatergic signaling to healthy aging.
Vaida Juozaityte, Chiara Pregnolato, Steffen Abay‐Nørgaard, Dylan Matthew Rausch, Rebecca L. McIntyre, Zachary Gerhart‐Hines, Tune H. Pers, Anna Elisabetta Salcini, Christoffer Clemmensen   +8 more
wiley   +1 more source

Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport. [PDF]

Drug Deliv
Weber L, O'Brien BCV, Weltzin MM.
europepmc   +1 more source

Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis

, 2009
Chris Ulens, Atilla Akdemir, Aldo Jongejan, René van Elk, Sonia Bertrand, Anastassis Perrakis, Rob Leurs, August B. Smit, Titia K. Sixma, Daniel Bertrand, Iwan J. P. de Esch   +10 more
openalex   +2 more sources

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma. [PDF]

Cancer Med
Lin CM, Lin LW, Chen TC, Ye YL, Chiang BL.   +4 more
europepmc   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source

Serum Levels of Alpha7 Nicotinic Acetylcholine Receptor and Their Association With Cardiovascular Autonomic Function Tests in Healthy Young Adults. [PDF]

Cureus
Karthik S, Elakiya M, Balamurugesan K.
europepmc   +1 more source

Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2‐Dependent Modulation of Subthreshold Currents

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo, Gabriel M. de Queiroz, Sérgio Ruschi B. Silva, Werner Treptow, Katarina E. Leao   +4 more
wiley   +1 more source

Antifibrotic Effects of an α7 Nicotinic Acetylcholine Receptor Agonist in Keloid Fibroblasts and a Rat Scar Model. [PDF]

Int J Mol Sci
Roh H, Kim YH, Heo KJ, Hong JW, Lee WJ.
europepmc   +1 more source

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

, 2013
Rilei Yu, Shiva N. Kompella, David J. Adams, David J. Craik, Quentin Kaas   +4 more
openalex   +1 more source