Results 191 to 200 of about 77,143 (337)

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application

MedComm, Volume 6, Issue 6, June 2025.
Before the cancer cells arrive to the lung through blood vessels, these cancer cells secreted specific factors for two main purposes: first, to recruit bone marrow‐derived cells; and second, to regulate the activation of target cells. Additionally, the unique structure of the lungs provides a comfortable environment. Consequently, the formation of lung
Chenghao Cao, Di Lu, Huigang Li, Shen Pan, Jianyong Zhuo, Zuyuan Lin, Chiyu He, Peiru Zhang, Songmin Ying, Xuyong Wei, Shusen Zheng, Zhe Yang, Xiao Xu   +12 more
wiley   +1 more source

Vagus nerve stimulation as a modulator of feedforward and feedback neural transmission [PDF]

arXiv
Vagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, and stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood.
arxiv  

Ca2+-dependent and cAMP-dependent Control of Nicotinic Acetylcholine Receptor Phosphorylation in Muscle Cells

, 1989
McHardy M. Smith, John P. Merlie, John C. Lawrence   +2 more
openalex   +1 more source

Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila [PDF]

, 1986
Irm Hermans‐Borgmeyer, Dieter Zopf, Rolf -Peter Ryseck, Bernd Hovemann, Heinrich Betz, Eckart D. Gundelfinger   +5 more
openalex   +1 more source

Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz, Charlotte Playle, Monika Palchaudhuri, Oliver Hucke, Ulrike Gross, Daniel Ursu   +5 more
wiley   +1 more source

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor. [PDF]

, 1990
Steen E. Pedersen, Jonathan B. Cohen
openalex   +1 more source

Cyclization of the Analgesic α‐Conotoxin Vc1.1 With a Non‐Natural Linker: Effects on Structure, Stability, and Bioactivity

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
This study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Yuhui Zhang, Han Shen Tae, David J. Adams, Thomas Durek, David J. Craik   +4 more
wiley   +1 more source

Triphenylmethylphosphonium is an ion channel ligand of the nicotinic acetylcholine receptor.

, 1982
L Lauffer, Ferdinand Hucho
openalex   +1 more source

Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies

Addiction Biology, Volume 30, Issue 6, June 2025.
ABSTRACT Substance use disorder constitutes a global health challenge. Preclinical investigations into addiction heavily rely on animal models to explore the underlying biological mechanisms of addictive disorders, with a particular emphasis on understanding the etiological factors influencing drug intake.
Leonardo Vázquez‐Morales, Gisela Aguirre, Tania Molina‐Jiménez, Rossana C. Zepeda, Óscar López‐Franco, Mónica Flores‐Muñoz, Claudia Juárez‐Portilla   +6 more
wiley   +1 more source

Block by Phytoestrogens of Recombinant Human Neuronal Nicotinic Receptors

Journal of Pharmacological Sciences, 2003
: The effects of phytoestrogens on neuronal nicotinic acetylcholine receptor/channels were examined by expressing recombinant channels in Xenopus oocytes.
Ken Nakazawa, Yasuo Ohno
doaj