Results 51 to 60 of about 35,918 (216)

Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia

Neurobiology of Disease, 2019
Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs, Xueliang Fan, Christine Donsante, H.A. Jinnah, Ellen J. Hess   +4 more
doaj   +1 more source

Autoimmunity to neuronal nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell types, participating in various functions of cells, tissues and systems. In this review, we focus on the autoimmunity against neuronal nAChRs, the specific autoantibodies and their mechanisms of pathological action in selected autoimmune diseases.
Pechlivanidou, M., Ninou, E., Karagiorgou, K., Tsantila, A., Mantegazza, R., Francesca, A., Furlan, R., Dudeck, L., Steiner, J., Tzartos, J., Tzartos, S.   +10 more
openaire   +4 more sources

Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes

Cellular Physiology and Biochemistry, 2016
Background/Aims: Oxidative stress induced intracellular Ca2+ overload plays an important role in the pathophysiology of several heart diseases. Acetylcholine (ACh) has been shown to suppress reactive oxygen species generation during oxidative stress ...
Siripong Palee, Nattayaporn Apaijai, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn   +4 more
doaj   +1 more source

Nicotinic acetylcholine receptors as targets for antidepressants [PDF]

Molecular Psychiatry, 2002
While the monoamine deficiency hypothesis of depression is still most commonly used to explain the actions of antidepressant drugs, a growing body of evidence has accumulated that is not adequately explained by the hypothesis. This article draws attention to contributions from another apparently common pharmacological property of antidepressant ...
R D, Shytle, A A, Silver, R J, Lukas, M B, Newman, D V, Sheehan, P R, Sanberg   +5 more
openaire   +2 more sources

Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea.
Baptiste Ganachaud, María José Mendoza‐León, Justine Marchix, Alonso Fernandez Tello, Catherine Le Berre Scoul, Ma Cecilia Opazo, Michel Neunlist, Claudia A. Riedel, Martial Caillaud, Hélène Boudin   +9 more
wiley   +1 more source

Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat

Biochemistry and Biophysics Reports, 2017
Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination.
R. Chinthu, T.R. Anju, C.S. Paulose
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Variations in “Functional Site” Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Toxins
Three-finger toxins (3FTxs) are the largest group of nonenzymatic toxins found in snake venoms. Among them, neurotoxins that target nicotinic acetylcholine receptors are the most well-studied ligands.
R. Manjunatha Kini, Cho Yeow Koh
doaj   +1 more source

Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning.

PLoS ONE, 2023
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C.
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor   +6 more
doaj   +1 more source

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source