Results 71 to 80 of about 1,317,031 (279)

Studying the function of α7 nicotinic acetylcholine receptor in Drosophila humoral immunity

, 2023
Acetylcholine (ACh) is one the major neurotransmitters, whose role in mediating synaptic interactions between neurons in the central nervous system in vertebrates and invertebrates is well characterized.
Giulia Cattabriga, Giuseppe Gargiulo, Giorgia Giordani, Silvia Gigliotti, Ilaria Di Lelio, Andrea Becchimanzi, Giovanna De Leva, Francesco Pennacchio   +7 more
core  

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat

Biochemistry and Biophysics Reports, 2017
Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination.
R. Chinthu, T.R. Anju, C.S. Paulose
doaj   +1 more source

Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia [PDF]

, 2010
The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia.
川崎, 博己, 荒木, 博陽, 45288, 45289, 鴻海, 俊太郎, 町支, 臣成, 45291, 末丸, 克矢, 45290, 日比野, 俐, 45293, 45292   +11 more
core  

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Dolga, A.,, Eisel, U.L.M.,, Dolga, Amalia, Dere, E., I. Pieri, L. Marchetti, Dere, E.,, Pieri, I., Marchetti, L., De Souza Silva, M. A., Huston, J. P., Marchetti, L.,, A. Dolga, J. P. Huston, Dolga, Amalia; id_orcid, U. L. M. Eisel, Huston, J.P.,, Pieri, I.,, Eisel, U. L. M., Souza Silva, M.A. De,, E. Dere, M. A. De Souza Silva, Eisel, U. L. M.; id_orcid   +22 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Variations in “Functional Site” Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Toxins
Three-finger toxins (3FTxs) are the largest group of nonenzymatic toxins found in snake venoms. Among them, neurotoxins that target nicotinic acetylcholine receptors are the most well-studied ligands.
R. Manjunatha Kini, Cho Yeow Koh
doaj   +1 more source

Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning.

PLoS ONE, 2023
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C.
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor   +6 more
doaj   +1 more source

Structure of nicotinic acetylcholine receptors

Current Opinion in Neurobiology, 1993
Nicotinic acetylcholine (ACh) receptors convert the binding of ACh into the opening of a cation-conducting channel. New information about the regions of the receptor most immediately involved in its function, namely the ACh-binding sites, the gate and the channel, has come from two approaches.
openaire   +2 more sources

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

Arthritis Research & Therapy, 2016
Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.The presence of nAChR subunits as well as the in-vitro effects of nAChR agonists were investigated by ex vivo osteoclastogenesis assays, real-time polymerase chain reaction, Western blot and flow cytometry in ...
Mandl P, Hayer S, Karonitsch T, Scholze P, Győri, Dávid Sándor, Sykoutri D, Blüml S, Mócsai, Attila, Poór, Gyula, Huck S, Smolen JS, Redlich K   +11 more
openaire   +3 more sources