Results 81 to 90 of about 1,317,031 (279)

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source

Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons

Scientific Reports
The neurotransmitter acetylcholine supports goal-directed cognitive functions via activation of its nicotinic and muscarinic classes of receptors within the prefrontal cortex.
Ashutosh V. Patel, Anthony Nguyen, Ashley A. Geremia, Donia Zeng, Pietro Paletta, Elena Choleris, Craig D. C. Bailey   +6 more
doaj   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Chronic exposure to imidacloprid increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris) [PDF]

, 2015
This work was funded jointly by the Biotechnology and Biological Sciences Research Council, the Department for Environment, Food and Rural Affairs, the Natural Environment Research Council, the Scottish Government, and The Wellcome Trust, under the ...
Bollan, Karen A., Connolly, C.N., Moffat, C., Buckland, Stephen Terrence, Goncalves Pacheco, J., Huang, Jeffrey; id_orcid, Buckland, Stephen T., Pacheco, Joao Goncalves, Moffat, Christopher, Samson, A.J., Connolly, Christopher N., Bollan, K.A., Sharp, Sheila, Samson, Andrew J., Sharpe, S., Huang, J.   +15 more
core   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Nicotinic Acetylcholine Receptor α7 Subunit Mediates Migration of Vascular Smooth Muscle Cells Toward Nicotine

Journal of Pharmacological Sciences, 2004
GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine ...
Sheng Li, Tiejun Zhao, Hong Xin, Li-Hong Ye, Xiaodong Zhang, Hideyuki Tanaka, Akio Nakamura, Kazuhiro Kohama   +7 more
doaj   +1 more source

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity [PDF]

, 2010
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes.
Kaprio J, Pillai S, Martin NG, Saccone NL, Leppert Mark F., Marissa A Ehringer, Wang, Jen C., Witt, Stephanie H., Jensen, Majken K., Sarah H. Stephens, Younghun Han, Peter Kraft, Amos Christopher I., Robert B Weiss, Culverhouse, Robert C., Broderick Peter, Stephanie H Witt, Bierut Laura J., Maria Teresa L, Culverhouse Robert C., Breslau Naomi, Markus M. Nöthen, Gapstur Susan M., Niu, Tianhua, Jen C Wang, Han, Younghun, Witt Stephanie H., Heliovaara, Markku, Thomas J Payne, Andrew C. Heath, Han, Shizhong, Landi MT, Kaprio, Jaakko, Yang BZ, Martin, Nicholas G., Gapstur, Susan M., Kendler KS, Wheeler William, Yufei Wang, Witt SH, Kendler Kenneth S., Wheeler, William, John P. Rice, Kaisu Keskitalo-Vuokko, Hunter David J., Margaret R Spitz, Sarah H Stephens, Ann Schwartz, Spitz, Margaret R., Nancy L. Saccone, Stephens SH, Ming D. Li, Wang JC, Dale S Cannon, Leena Peltonen, David J Hunter, Angela S. Wenzlaff, Andrew C Heath, Caporaso Neil E., Weiss Robert B., Hoft, Nicole R., Payne Thomas J., Neil E. Caporaso, Keskitalo-Vuokko, Kaisu, Landi, Maria Teresa, Breslau N, Sven Cichon, Xiangyang Kong, Breslau, Naomi, Hoft NR, Rietschel Marcella, Stevens VL, Noethen, Markus M., Nöthen, Markus M., Michele L Pergadia, Heliövaara M, Laura J Bierut, Chatterjee N, Michele L. Pergadia, Susan E Short, Robert C Culverhouse, Ina Giegling, Sun Lingwei, Chen X, Kaprio Jaakko, Jensen MK, Stephens Sarah H., Sherva R, Laura J. Bierut, Chen J, Li MD, Heath AC, Nicole R. Hoft, Majken K Jensen, Broderick P, Stevens Victoria L., Martin Nicholas G., Sherva, Richard, Marcella Rietschel, Aggen SH, Nancy L Saccone, Stephens, Sarah H., Peltonen, Leena, Sreekumar Pillai, Cannon Dale S., Sun, Lingwei, Eisen Tim, Mark F. Leppert, Angela S Wenzlaff, Giegling Ina, Bierut LJ, Heliovaara, Marku, Maria Teresa Landi, Pergadia Michele L., Markku Heliövaara, Hunter DJ, Stevens, Victoria L., Kenneth S Kendler, Keskitalo-Vuokko Kaisu, Cannon, Dale S., Ehringer, Marissa A., Schwantes-An Tae-Hwi, Landi, Maria T., Thomas J. Payne, Li Ming D., Peter Broderick, Montgomery GW, Cichon, Sven, Jingchun Chen, John P Rice, Han Younghun, Wang Jen C., Chen Jingchun, Aggen Steven H., Rujescu D, Nicholas G Martin, Rice John P., Pergadia, Michele L., Jennie Z Ma, Yang Bao-Zhu, Eisen T, Marissa A, Nilanjan Chatterjee, Hunter, David J., Madden Pamela A. F., Victoria L. Stevens, Neil E Caporaso, Sun, Juzhong, Steven H Aggen, Nicholas G. Martin, Kenneth S. Kendler, Chen, Xiangning, Cichon S, Landi Maria Teresa, Joel Gelernter, Mark F Leppert, William Wheeler, Gelemter, Joel, Heliövaara Markku, Kraft Peter, Susan E. Short, Saccone Nancy L., Gelernter Joel, Susan M. Gapstur, Chen, Jingchun, Cichon Sven, Wenzlaff AS, Tim Eisen, Heath Andrew C., Madden PA, Pillai, Sreekumar, Robert C. Culverhouse, Lingwei Sun, Chen Xiangning, Rice, John P., Bao-Zhu Yang, Chatterjee, Nilanjan, Richard Houlston, Kraft, Peter, Majken K. Jensen, Rice JP, Shizhong Han, Nicole R Hoft, Pergadia ML, Saccone, Nancy L., Ming D Li, Han Y, Sherva Richard, Montgomery Grant W., Han S, Culverhouse RC, Victoria L Stevens, Kong Xiangyang, Wheeler W, Pamela A F Madden, Dan Rujescu, Ma JZ, Gapstur SM, Steven H. Aggen, Christopher I. Amos, Wenzlaff Angela S., Schwartz Ann, Caporaso NE, Cannon DS, Hoft Nicole R., Short, Susan E., Tianhua Niu, Jen C. Wang, Eisen, Tim, Leppert MF, Wang Yufei, Niu Tianhua, Caporaso, Neil E., Heath, Andrew C., Kong, Xiangyang, Broderick, Peter, Schwartz, Ann, Juzhong Sun, Wenzlaff, Angela S., Weiss, Robert B., Bierut, Laura J., Peltonen L, Rujescu, Dan, Kong X, Yang, Bao-Zhu, Wang, Yufei, Christopher I Amos, Houlston R, Rujescu Dan, Weiss RB, Susan M Gapstur, Houlston Richard, Rietschel M, Schwantes-An, Tae-Hwi, Leppert, Mark F., Giegling, Ina, Richard Sherva, Montgomery, Grant W., Sun L, Amos CI, Gelernter J, Li, Ming D., Schwantes-An TH, Ehringer MA, Ma, Jennie Z., Sun Juzhong, Wang Y, Sun J, Kendler, Kenneth S., Xiangning Chen, Palotie, Leena, Payne TJ, Tae-Hwi Schwantes-An, Jaakko Kaprio, Nöthen Markus M., Naomi Breslau, Marissa A. Ehringer, Aggen, Steven H., Payne, Thomas J., Robert B, Kraft P, Grant W Montgomery, Margaret R. Spitz, Chatterjee Nilanjan, Spitz Margaret R., Houlston, Richard, Keskitalo-Vuokko K, Ma Jennie Z., David J. Hunter, Niu T, Stephanie H. Witt, Short Susan E., Rietschel, Marcella, Nöthen MM, Schwartz A, Grant W, Pillai Sreekumar, Markus M Nöthen, Pamela A. F. Madden, Han Shizhong, Amos, Christopher I., Giegling I, Dale S. Cannon, Grant W. Montgomery, Jensen Majken K., Spitz MR, Peltonen Leena, Gelernter, Joel, Jennie Z. Ma, Pamela A. F, Short SE, Robert B. Weiss, Madden, Pamela A. F., Ehringer Marissa A., Culverhouse, Robert C, Madden, Pamela A.F, Hunter, David, Jensen, Majken, Heath, Andrew C, Bierut, Laura J, Rice, John P, et al.,, Pergadia, Michele L, Short, Susan, Wang, Jen C, Saccone, Nancy L   +305 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source