Results 101 to 110 of about 35,918 (216)

Nicotinic acetylcholine receptors

Scholarpedia, 2008
Pierre-Jean Corringer, Jean-Pierre Changeux   +1 more
openaire   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg, Ziyaan A. Harji, Christian J. Rampal, Joséphine Sacy‐Richer, Amy Wang, Esteban C. Rodríguez, Gary A. B. Armstrong   +6 more
wiley   +1 more source

Müller Glia–Vasculature Interactions in the Developing Retina

Glia, Volume 74, Issue 10, October 2026.
Retinal vascular layers form normally despite loss of cholinergic retinal waves. Müller glial processes contact endothelial tip cells early and form Aquaporin‐4‐enriched endfeet. Glial endfoot calcium signals are compartmentalized and occur largely independently of neural activity. ABSTRACT Coordinated signaling among neurons, glia, and the vasculature
Samira Monshietehadi, Angel J. Garcia, Benjamin E. Smith, Matthew Tarchick, Kiara Abhayaratne, Aileen Conley, Marla B. Feller   +6 more
wiley   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, Volume 46, Issue 9, Page 3164-3176, September 2026.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Species composition of blow flies (Diptera: Calliphoridae) colonizing pig carcasses exposed to bifenthrin‐ and clothianidin‐containing products

Medical and Veterinary Entomology, Volume 40, Issue 3, Page 574-581, September 2026.
High clothianidin concentrations prevented colonization, while bifenthrin showed a non‐significant trend of reduced fly abundance, indicating both insecticides may suppress blow fly activity on treated carcasses. Adult emergence rates were unaffected, with no statistically significant differences observed across insecticide treatments, suggesting ...
Teomie S. Rivera‐Miranda, Krystal R. Hans   +1 more
wiley   +1 more source