Results 111 to 120 of about 35,918 (216)

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo, Monique van Velzen, Simone C. Jansen, Maarten van Lemmen, Elise Sarton, Albert Dahan, Erik Olofsen, Joseph F. Cotten, Marieke Niesters, Rutger M. van der Schrier   +9 more
wiley   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, Volume 41, Issue 8, Page 507-522, August 2026.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Altered Functional Connectivity in the Reward Circuit in Betel Quid‐Dependent Chewers

Addiction Biology, Volume 31, Issue 8, August 2026.
Resting‐state fMRI identified abnormal functional connectivity within the reward circuit in individuals with betel quid dependence, involving the ventral striatum, prefrontal cortex, posterior cingulate cortex and thalamus. Reduced connectivity between the thalamus and posterior cingulate cortex was related to dependence severity and BQ dosage.
Yuegui Cao, Sisi Chen, Jiayu Li, Lingyu Kong, Jincheng He, Fulai Yuan, Jing He, Xueling Zhu   +7 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Illuminating the Future of Catecholamine Detection

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Catecholamines such as dopamine and norepinephrine are key signaling molecules in our body. We discuss how fluorescent sensors (carbon nanotube based and genetically encoded) for these molecules in combination with novel imaging methods and kinetic data analysis enable new biological experiments.
Julia Ackermann, Andreas Reiner, Sebastian Kruss   +2 more
wiley   +1 more source

Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor. [PDF]

Proc Natl Acad Sci U S A
Webster RG, Alabaf S, Li A, Beerli R, Siehler S, Imbert PE, Lee L, Cossins J, Koziczak-Holbro M, Flotte L, Gaudet L, Gerwin N, Beeson D, Dong YY.   +13 more
europepmc   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor. [PDF]

Adv Sci (Weinh)
Wang Y, Deng Y, Xia N, Sugita S, Gao S.
europepmc   +1 more source

Pan-cancer expression, methylation, and prognostic significance of α7 nicotinic acetylcholine receptor in tumor immunology. [PDF]

Biochem Biophys Rep
Bai X, Ma T, Shi L, Wang P, Zhao D, Long J, Hai Y, You Y, Zhao R, Ma L.   +9 more
europepmc   +1 more source

Novel Nicotinic Acetylcholine Receptor Inhibitors Derived from Oleoylcholine Analogs. [PDF]

Acta Naturae
Vladykina MV, Kokaeva IS, Kasheverov IE, Gretskaya NM, Zinchenko GN, Tsetlin VI, Utkin YN, Bezuglov VV, Shelukhina IV.   +8 more
europepmc   +1 more source