Results 101 to 110 of about 35,240 (226)

Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta‐Analysis

Acta Paediatrica, Volume 115, Issue 7, Page 1413-1428, July 2026.
ABSTRACT Aim Nicotine exposure during pregnancy interferes with critical periods of foetal brain development, disrupting the timing and functioning of neurodevelopment. This systematic review and meta‐analysis aims to evaluate the effect of prenatal nicotine exposure on postnatal cognitive outcomes.
Deimantė Baguckaitė, Judith Covey, Nadja Reissland   +2 more
wiley   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch, Melanie J. Miller, Shaveta Kanoria, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco, Jesús Andrade‐Guerrero, Nelly Jovana Pastén‐Castrejón, Chryslaine Rodríguez‐Tanty, Sofía Y Diaz‐Miranda   +4 more
wiley   +1 more source

Comparing Efficacy and Safety of Various Monoclonal Antibodies in Myasthenia Gravis: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 16, Issue 6, June 2026.
ROZ 10 mg/kg ranked best for reducing MG‐ADL. BAT 680 mg significantly reduced QMG and ranked best. BAT 340 mg had the highest probability of reducing the MGC score. ECU significantly decreased MG‐QoL 15r and ranked best. BEL 10 mg/kg had the highest likelihood of reducing adverse events.
Muhammad Hassan Waseem, Zain ul Abideen, Minahil Iqbal, Saniya Ishtiaq, Pawan Kumar Thada, Adam A. Dmytriw   +5 more
wiley   +1 more source

Structure‐Guided Surface Engineering of an Artificial Metallolyase for Highly Enantioselective Michael Addition

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
X‐ray visualization of copper‐binding modes revealed nonspecific surface metal sites that compromise stereoselectivity. Structure‐guided mutations suppressed background reactivity and enabled precise enantioselective control in the Michael addition, delivering up to 99% ee.
Saito Morikawa, Naoki Saegusa, Ryusei Matsumoto, Yoshitsugu Morita, Nobutaka Fujieda   +4 more
wiley   +1 more source

Selective Rh(II)‐Catalyzed Intermolecular Oxyamidation and Acid‐Promoted Nucleophilic Cyclization Cascade of Enamides

ChemistryEurope, Volume 4, Issue 6, June 2026.
A structurally diverse series of 1‐amino‐izidine scaffolds was accessed through a cascade process combining rhodium‐catalyzed nitrene‐transfer oxyamidation with subsequent nucleophilic cyclization under acidic conditions, proceeding via an in situ generated iminium intermediate.
Grégory Jestin, Romain Rey‐Rodriguez, Romane Manguin, Pascal Retailleau, Philippe Dauban, Isabelle Gillaizeau   +5 more
wiley   +1 more source

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula

Journal of Comparative Neurology, Volume 534, Issue 6, June 2026.
Mu opioid receptor (MOR) mRNA was detected with RNAscope in situ hybridization for Oprm1 and protein was detected with immunocytochemistry to map the distributions across the anterior‐posterior extent of the rat and mouse habenula. Expression distribution was also characterized in a transgenic reporter mouse line (Oprm1‐Venus/Venus) as an additional ...
Aashka K. Popat, Rhiana C. Simon, Beatriz B. Aoyama, Ahana Wokhlu, Aliza T. Ehrlich, Corey C. Harwell, Elyssa B. Margolis   +6 more
wiley   +1 more source