Results 1 to 10 of about 29,026 (188)

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]

Molecules, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika, Koch, Christian, Magel, Ilona, McIntosh, J. Michael, Padberg, Winfried, Perniss, Alexander, Richter, Katrin, Sander, Michael, Schweda, Elke K. H., Wichmann, Sven, Wilker, Sigrid, Wolf, Philipp M.   +11 more
core   +3 more sources

Functional expression and properties of the tick α6 homomeric nicotinic acetylcholine receptor in <i>Xenopus laevis</i> oocytes. [PDF]

Curr Res Parasitol Vector Borne Dis
Recent studies have suggested that the tick Ixodes ricinus expresses nAChR subtypes which are activated by acetylcholine. Here, we investigated the potential of the Iricα6 subunit to form a functional receptor when expressed in Xenopus laevis oocytes ...
Cartereau A, Boussaine K, Taillebois E, Thany SH.   +3 more
europepmc   +2 more sources

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy. [PDF]

PLoS One
The standard treatment of atropine and oximes is insufficiently effective against all organophosphorus nerve agents. Bispyridinium non-oxime nicotinic antagonists are promising components to add to treatments.
Turner SR, Timperley CM, Bird M, Green AC, Price ME, Rice H, Chad JE, Tattersall JEH.   +7 more
europepmc   +2 more sources

Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors.

PLoS ONE, 2021
Cholinergic modulation of hippocampal network function is implicated in multiple behavioral and cognitive states. Activation of nicotinic and muscarinic acetylcholine receptors affects neuronal excitability, synaptic transmission and rhythmic ...
Olha Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr Maximyuk, Murat Oz, Gregory L Holmes, Oleg Krishtal, Dmytro Isaev   +7 more
doaj   +1 more source

Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors

Pharmacological Research, 2023
The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the last decade, due to a) the improved techniques available for structural studies; b) the identification of ligands interacting at orthosteric and allosteric ...
Carlo Matera, Claudio Papotto, Clelia Dallanoce, Marco De Amici   +3 more
doaj   +1 more source

The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis

Frontiers in Immunology, 2021
The cholinergic system is present in both bacteria and mammals and regulates inflammation during bacterial respiratory infections through neuronal and non-neuronal production of acetylcholine (ACh) and its receptors.
Leon Islas-Weinstein, Brenda Marquina-Castillo, Dulce Mata-Espinosa, Iris S. Paredes-González, Jaime Chávez, Luciana Balboa, José Luis Marín Franco, Daniel Guerrero-Romero, Jorge Alberto Barrios-Payan, Rogelio Hernandez-Pando   +9 more
doaj   +1 more source

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]

PLoS ONE, 2015
Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersall   +8 more
doaj   +1 more source

Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models

Acta Pharmaceutica Sinica B, 2021
Nicotinic α4β2 receptor antagonists have drawn increasing attention in the development of new antidepressants. In this study, we aimed to investigate the protective effect of VMY-2-95, the new selective antagonist of α4β2 nicotinic acetylcholine receptor
Ziru Yu, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du   +4 more
doaj   +1 more source

Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy

eNeurologicalSci, 2022
Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments
Sarah Westlake, Matthew Jones, Krishna D. Sharma, Jennifer Yanhua Xie   +3 more
doaj   +1 more source

Effects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosum [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Endocannabinoids and nicotine regulate the neurotransmitter release in different central and peripheral synapses. Various studies in the literature demonstrate the interaction between endocannabinoid and nicotinic systems, especially in the
İsmail Mert Vural, Gokce Sevim Ozturk Fincan, Derya Sebile Koc, Yagmur Okcay, Celil İlker Askin, Ayse Kubra Kibar, Sevil Ozger Ilhan, Yusuf Sarioglu   +7 more
doaj   +1 more source