Results 121 to 130 of about 29,145 (307)

Neonicotinic analogues: Selective antagonists for α4β2 nicotinic acetylcholine receptors

Bioorganic & Medicinal Chemistry, 2013
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to design and synthesise novel α4β2-preferring neonicotinic ligands.
Faundez Parraguez, Manuel, Farias Rabelo, Nicolas, Gonzalez Gutierrez, Juan Pablo, Etcheverry Berrios, Alvaro, Alzate Morales, Jans, Adasme-Carreño, Francisco, Varas, Rodrigo, Bermúdez, Isabel, Iturriaga-Vásquez, Patricio   +8 more
openaire   +3 more sources

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Ischemic Stroke Burden in China and Other G20 Nations (1990–2021): A Comparative Analysis From the Global Burden of Disease Study 2021 and Trend Projections Through 2031

Health Care Science, EarlyView.
This study analyzes ischemic stroke (IS) burden in China and other G20 countries (1990–2021) using Global Burden of Disease 2021 data. China exhibited rising age‐standardized incidence rates (ASIR: +12.6%) and delayed mortality decline, contrasting with G20 reductions (ASIR: −9.3%; sustained ASMR fall).
Bin Luo, Yi Xiang, Hecheng Ren, Lin Ma, Ying Huang   +4 more
wiley   +1 more source

Experimental Factors and Techniques for Pool Boiling Heat Transfer Enhancement: A Critical Review

Heat Transfer, EarlyView.
ABSTRACT This review presents a comprehensive assessment of active strategies for enhancing pool boiling heat transfer, with a focus on techniques that do not rely solely on the boiling surface modification. It examines a broad range of methodologies including fluid additives, external fields, mechanical interventions, and thermal‐geometric tuning that
José E. Pereira, R. R. Souza, A. S. Moita   +2 more
wiley   +1 more source

Optimizing outcomes in intrauterine insemination: A narrative synthesis of two decades of clinical research (2000–2024)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Intrauterine insemination (IUI) is a widely used first‐line fertility treatment, yet its success rates vary considerably. This review synthesizes evidence from peer‐reviewed studies published between 2000 and 2024, including randomized controlled trials, cohort and case–control studies, as well as systematic and narrative reviews identified ...
Kasuni Akalanka
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Chronic Nicotine Treatment Upregulates L-Type High Voltage-Gated Calcium Channels

Journal of Pharmacological Sciences, 2005
Neurochemical mechanisms underlying drug dependence and withdrawal syndrome remain unclear. In this review, we discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide ...
Masashi Katsura, Seitaro Ohkuma
doaj   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes

Frontiers in Immunology, 2019
Type I diabetes (T1D) is a T cell-driven autoimmune disease that results in the killing of pancreatic β-cells and, consequently, loss of insulin production.
Maria J. Fernández-Cabezudo, Junu A. George, Ghada Bashir, Yassir A. Mohamed, Alreem Al-Mansori, Mohammed M. Qureshi, Dietrich E. Lorke, Georg Petroianu, Basel K. al-Ramadi, Basel K. al-Ramadi   +9 more
doaj   +1 more source

Comparative efficacy of novel bioactive glass versus sodium fluoride toothpaste for dentin hypersensitivity

Journal of Periodontology, EarlyView.
Abstract Background This first‐in‐human clinical study aimed to evaluate the safety and efficacy of a bioglass incorporated in a toothpaste, in reducing dentin hypersensitivity (DH) compared to a sodium fluoride (NaF) toothpaste over a 2‐week period. Methods A double‐blind, randomized, parallel‐arm, proof‐of‐concept clinical trial was conducted with 46
Hatice Hasturk, Daniel Boyd, Kathleen MacDonald‐Parsons, Stephanie Turner‐Cahill, Joon Seong, Nicola West, Heather J. Doucette   +6 more
wiley   +1 more source