Results 11 to 20 of about 29,145 (307)

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish [PDF]

Molecules, 2020
Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs.
Franco Viscarra, Juan González-Gutierrez, Erica Esparza, Carla Figueroa, Pablo Paillali, Martin Hödar-Salazar, Camilo Cespedes, Gabriel Quiroz, Ramón Sotomayor-Zárate, Miguel Reyes-Parada, Isabel Bermúdez, Patricio Iturriaga-Vásquez   +11 more
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Small molecule ligands for α9 * and α7 nicotinic receptors: A survey and an update, respectively

Pharmacological Research, 2023
The α9- and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate numerous physiological and pathological processes by complex mechanisms that are currently the subject of intensive study and debate.
Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi   +2 more
doaj   +1 more source

Nicotinic Receptor Antagonists as Treatments for Nicotine Abuse [PDF]

, 2014
Despite the proven efficacy of current pharmacotherapies for tobacco dependence, relapse rates continue to be high, indicating that novel medications are needed. Currently, several smoking cessation agents are available, including varenicline (Chantix®), bupropion (Zyban®), and cytisine (Tabex®).
Peter A, Crooks, Michael T, Bardo, Linda P, Dwoskin   +2 more
openaire   +2 more sources

Discovery of novel α7 nicotinic receptor antagonists [PDF]

Bioorganic & Medicinal Chemistry Letters, 2010
Two distinct families of small molecules were discovered as novel alpha7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal alpha7 subtype over other nAChRs and good brain penetration.
Intra-Cellular Therapies, Inc., New York, NY, United States ( host institution ), Peng, Youyi ( author ), Zhang, Qiang ( author ), Snyder, Gretchen L. ( author ), Zhu, Hongwen ( author ), Yao, Wei ( author ), Tomesch, John ( author ), Papke, Roger L. ( author ), O’Callaghan, James P. ( author ), Welsh, William J. ( author ), Wennogle, Lawrence P. ( author )   +10 more
openaire   +3 more sources

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Nicotinic antagonist effects on functional attention networks [PDF]

The International Journal of Neuropsychopharmacology, 2009
Cholinergic neurotransmission has been implicated in memory and attention. We investigated the effect of the non-competitive nicotinic antagonist mecamylamine on three components of attention processes (i.e. alerting, orienting and executive control) in 12 healthy male subjects whilst performing the Attention Network Task (ANT) in a magnetic resonance ...
Thienel, Renate, Voss, Bianca, Kircher, Tilo, Kellermann, Thilo, Reske, Martina, Halfter, Sarah, Sheldrick, Abigail J., Radenbach, Katrin, Habel, Ute, Shah, Nadim Jon, Schall, Ulrich   +10 more
openaire   +3 more sources

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer

Journal of Pharmacological Sciences, 2008
Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
doaj   +1 more source

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]

, 2009
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen, Fuchs, Paul A., Katz, Eleonora   +2 more
core   +1 more source

Mecamylamine (a nicotine antagonist) for smoking cessation [PDF]

Cochrane Database of Systematic Reviews, 1998
Mecamylamine is a nicotine antagonist (that is it blocks the effect of nicotine). The rationale for its use in smoking cessation is that it may block the rewarding effect of nicotine and thus reduce the urge to smoke.The objective of this review was to determine the effectiveness of mecamylamine in promoting smoking cessation, either alone or in ...
Lancaster, T, Stead, L
openaire   +3 more sources