Results 261 to 270 of about 29,145 (307)

ChemInform Abstract: NONCLASSICAL NICOTINE ANTAGONISTS

Chemischer Informationsdienst, 1976
AbstractAus den p‐substituierten Diacetyl‐Aromaten (Ia)‐(Ic) entstehen mit Brom in Eisessig die entsprechenden Bromacetylverbindungen (IIa)‐(Ilc), die auch aus den Aromaten (IV) mit Bromacetylbromid (III) in Gegenwart von Aluminiumchlorid erhalten werden können.
C. F. BARFKNECHT, C. A. JUN. TAYLOR, L. A. PETERSON, F. M. SHARABI, J. P. LONG   +4 more
openaire   +1 more source

GABA A ANTAGONIST AND NICOTINE-INDUCED ANTINOCICEPTION

Life Sciences, 1997
Rats, pretreated with saline or GABA(A) antagonist bicuculline (BIC) at the doses of 2, 4, 6, 10 and 20 mg/kg, were injected with nicotine (NIC, 1 mg/kg) 30 min later. Tail-flick (TF) latencies were measured before (baseline) and three times at 10 min interval after pretreated compounds, continued every 10 min up to 1 hr after NIC injection.
W C, Mui, V K, Zbuzek, W H, Wu
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Selective dopamine antagonists reduce nicotine self-administration

Psychopharmacology, 1991
The effects of selective D1 (SCH23390) and D2 (spiperone) dopamine antagonists, as well as of haloperidol, were examined on nicotine self-administration, food-maintained responding, and locomotor activity in rats. Antagonists reduced both operant responding and locomotor activity.
W A, Corrigall, K M, Coen
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Modulation of synaptic transmission by nicotine and nicotinic antagonists in hippocampus

Brain Research Bulletin, 1999
Using rat hippocampal slices, we studied the effects of nicotine and three antagonists of neuronal nicotinic receptors on excitatory and inhibitory transmission. We report that nicotine at concentrations between 0.5 and 100 microM enhanced excitatory synaptic responses and increased the size of the presynaptic fiber volley.
Chiodini, F. C., Tassonyi, Edomer, Hulo, S., Bertrand, Daniel, Muller, Dominique   +4 more
openaire   +3 more sources

The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

Psychopharmacology, 1994
Recently, a rodent model of nicotine abstinence syndrome has been developed based on observing the frequency of spontaneous behavioral signs following termination of continuous subcutaneous infusion of nicotine tartrate. In the present study, the nicotinic antagonist mecamylamine precipitated an abstinence syndrome in nicotine-dependent rats.
D H, Malin, J R, Lake, V A, Carter, J S, Cunningham, K M, Hebert, D L, Conrad, O B, Wilson   +6 more
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Selective nicotinic receptor antagonists: effects on attention and nicotine-induced attentional enhancement

Psychopharmacology, 2011
The question of the subtype(s) of the nicotinic acetylcholine receptor (nAChR) mediating the attention-enhancing effects of nicotine is still unsettled. While early studies pointed towards subtypes other than the homomeric α7 nAChR, pro-cognitive effects of α7 nAChR agonists have since been demonstrated.This study tested whether the performance ...
Hahn, Britta, Shoaib, Mohammed, Stolerman, Ian P.   +2 more
openaire   +3 more sources

Nicotine Abstinence Syndrome Precipitated by the Competitive Nicotinic Antagonist Dihydro-β-Erythroidine

Pharmacology Biochemistry and Behavior, 1998
Rats infused subcutaneously with 9 mg/kg/day nicotine tartrate for 7 days exhibit behavioral abstinence signs following either termination of nicotine infusion or injection of the noncompetitive nicotinic antagonists mecamylamine (s.c.) or hexamethonium (ic.c.v.).
D H, Malin, J R, Lake, T P, Upchurch, M, Shenoi, N, Rajan, W E, Schweinle   +5 more
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Iptakalim as a Human Nicotinic Acetylcholine Receptor Antagonist

The Journal of Pharmacology and Experimental Therapeutics, 2006
Nicotinic acetylcholine receptors (nAChRs) play many critical roles in nervous system function and have been implicated in a variety of diseases. Drugs acting at nAChRs, perhaps in nAChR subtype-selective manners, can be used to dissect receptor function and perhaps as medications.
Jun, Hu, Kari, Lindenberger, Gang, Hu, Hai, Wang, Ronald J, Lukas, Jie, Wu   +5 more
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Neosurugatoxin, a Specific Antagonist of Nicotinic Acetylcholine Receptors

Journal of Neurochemistry, 1984
Abstract: Neosurugatoxin (NSTX) (3 nM‐30 nM), recently isolated from the Japanese ivory mollusc (Babylonia japonica) exerted a potent antinicotinic action in the isolated guinea pig ileum. Specific [3H]nicotine binding to rat forebrain membranes was saturable, reversible, and of high affinity.
E, Hayashi, M, Isogai, Y, Kagawa, N, Takayanagi, S, Yamada   +4 more
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Nicotine cue: lack of effect of the α7 nicotinic receptor antagonist methyllycaconitine

European Journal of Pharmacology, 1996
To assess the role of the alpha 7 neuronal nicotinic acetylcholine receptor in the discriminative stimulus properties of (-)-nicotine, this study investigated the ability of the alpha 7 receptor antagonist methyllycaconitine to modulate the nicotine cue.
J D, Brioni, D J, Kim, A B, O'Neill
openaire   +2 more sources