Results 271 to 280 of about 29,145 (307)

Induction of Fos-immunostaining by nicotine and nicotinic receptor antagonists in rat brain

Neuropharmacology, 2001
Using Fos protein immunohistochemistry, we have studied the effects of acute nicotine (0.5 mg/kg s.c.) and nicotinic acetylcholine receptor (nAChR) antagonists in eleven rat brain areas. Acute nicotine elevated Fos-like immunostaining (Fos IS) significantly in all studied areas except the medial prefrontal cortex.
T, Seppä, O, Salminen, M, Moed, L, Ahtee   +3 more
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The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat

Nicotine & Tobacco Research, 2001
Nicotinic acetylcholine receptor (nAChR) antagonists have been shown previously to decrease nicotine self-administration and precipitate elevations in brain reward thresholds and somatic signs of withdrawal in animals chronically exposed to nicotine. Both the positive-reinforcing effects of acute nicotine and the negative effects of nicotine withdrawal
A, Markou, N E, Paterson
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Nicotinic Agonists, Antagonists, and Modulators From Natural Sources

Cellular and Molecular Neurobiology, 2005
1. Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. Several further nicotinic agonists have been discovered from natural sources, including cytisine, anatoxin, ferruginine, anabaseine, epibatidine, and epiquinamide.
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Interaction of narcotic antagonist naltrexone with nicotinic acetylcholine receptor

European Journal of Pharmacology, 1987
The interactions of naltrexone with the nicotinic acetylcholine receptor were studied electrophysiologically using the frog sciatic nerve-sartorius muscle and biochemically using membranes from the electric organ of Torpedo ocellata. At nanomolar concentrations naltrexone increased the peak amplitude of endplate currents with little change in the decay
L, Oliveira, B W, Madsen, N, Kapai, S M, Sherby, K L, Swanson, M E, Eldefrawi, E X, Albuquerque   +6 more
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Could Nicotine Antagonists be Used in Smoking Cessation?

British Journal of Addiction, 1986
SummaryIt is widely accepted that tobacco use is primarily a problem of drug dependence, with nicotine serving as the addictive agent. Nicotine itself is of some value as a therapeutic aid for people trying to give up smoking. The possible applications in this area of a different class of drug, nicotine antagonists, are reviewed. The receptor mediating
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Histamine as an endogenous antagonist of nicotinic ACh-receptor

Brain Research, 1984
The mechanism of an inhibitory effect of histamine on the sensitivity of frog skeletal muscle endplate was analyzed by studying the dose-response relation between the quantity of ACh applied iontophoretically and the ACh-induced postsynaptic current (ACh current), and also the interaction between histamine and erabutoxin-b (ETX-b). The results obtained
Y, Ohta, M, Ariyoshi, K, Koketsu
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Opiate antagonists reduce cocaine but not nicotine self-administration

Psychopharmacology, 1991
Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion.
W A, Corrigall, K M, Coen
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Effects of the nicotinic antagonist mecamylamine on inspection time

Psychopharmacology, 2000
Several lines of evidence suggest that nicotinic acetylcholine receptors (nAchRs) are involved in speed of information processing, and inspection time appears to be particularly sensitive to nicotinic manipulation.The present study sought to examine the effects of the nAchR antagonist mecamylamine on inspection time.
Thompson, James C., Stough, Con, Ames, David, Nathan, Pradeep J., Ritchie, Craig   +4 more
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Agonists and Antagonists of Nicotinic Acetylcholine Receptors

2000
The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).
S. P. Arneric, M. W. Holladay
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Nicotinic agonist and antagonist effects on memory

Drug Development Research, 1996
Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...
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