Results 31 to 40 of about 29,145 (307)
Journal of Pharmacological Sciences, 2008 Mucocutaneous keratinocytes and bronchial epithelial cells express nicotinic acetylcholine receptors (nAChRs). Emerging evidence indicates that nAChRs can be stimulated also by the tobacco-derived nitrosamines 4-(methylnitrosamino)-1-(3–pyridyl)-1 ...
Sergei A. Grando
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Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors
Frontiers in Pharmacology, 2018 The α7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target.
Jhon J. López +3 more
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Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. [PDF]
PLoS ONE, 2011 We present a cell based system and experimental approach to characterize agonist and antagonist selectivity for ligand-gated ion channels (LGIC) by developing sensor cells stably expressing a Ca(2+) permeable LGIC and a genetically encoded Förster (or ...
John G Yamauchi +8 more
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r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement [PDF]
Neurochemical Research, 2015 α6β2* nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic neurons mediate nicotine-evoked dopamine (DA) release and nicotine reinforcement. α6β2* antagonists inhibit these effects of nicotine, such that α6β2* receptors serve as therapeutic targets for nicotine addiction. The present research assessed the neuropharmacology of 1,10-bis(3-
Joshua S, Beckmann +10 more
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Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
, 2016 Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark +5 more
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Cholinergic calcium responses in cultured antennal lobe neurons of the migratory locust
Scientific Reports, 2021 Locusts are advantageous organisms to elucidate mechanisms of olfactory coding at the systems level. Sensory input is provided by the olfactory receptor neurons of the antenna, which send their axons into the antennal lobe. So far, cellular properties of
Gregor A. Bergmann, Gerd Bicker
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Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior
Molecules, 2021 The popular tobacco and e-cigarette chemical flavorant (−)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs), and contributes to multiple physiological effects that exacerbates nicotine addiction ...
Skylar Y. Cooper +3 more
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Nicotine-mediated effects in neuronal and mouse models of synucleinopathy
Frontiers in Neuroscience, 2023 IntroductionAlpha-synuclein (α-Syn) aggregation, transmission, and contribution to neurotoxicity represent central mechanisms underlying Parkinson’s disease.
Mohamed Bilal Fares +20 more
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Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
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Marine Drugs, 2022 The α7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses.
Yao Tan +5 more
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