Results 41 to 50 of about 29,145 (307)
Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]
, 1997 Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A. +2 more
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SLAS Discovery, 2022 There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicotine,
Michelle Kassner +6 more
doaj +1 more source
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]
, 2008 We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel +81 more
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Frontiers in Pharmacology, 2018 Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovium or serum ...
MengFan Yue +7 more
doaj +1 more source
The kynurenine pathway and the brain: challenges, controversies and promises [PDF]
, 2017 Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
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THIAMINE AS A NICOTINE ANTAGONIST
Japanese Journal of Pharmacology, 1963 Serial studies have been brought about on the nicotine detoxication with special reference to the metabolic fate of nicotine (1-7) and also on the action mechanism of nicotine antagonists (8-12) by Yamamoto and his coworkers since 1951. The fact that thiamine possessed an antagonistic action on nicotine toxicity was firstly pointed out by Unna et al ...
openaire +3 more sources
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists [PDF]
ACS Chemical Neuroscience, 2016 A series of multitarget directed propargylamines, as well as other differently susbstituted piperidines have been screened as potential modulators of neuronal nicotinic acetylcholine receptors (nAChRs). Most of them showed antagonist actions on α7 nAChRs.
Criado, Manuel +9 more
openaire +3 more sources
Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
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Social Isolation: How Can the Effects on the Cholinergic System Be Isolated?
Frontiers in Pharmacology, 2021 Social species form organizations that support individuals because the consequent social behaviors help these organisms survive. The isolation of these individuals may be a stressor. We reviewed the potential mechanisms of the effects of social isolation
Jaromir Myslivecek
doaj +1 more source
Advanced Functional Materials, EarlyView.By mimicking the ion‐accelerating effect of ion channel receptors in neuron membranes, a biomaterials‐based ionic hydrogel (BIH) is developed, which offers a high ionic conductivity of 7.04 S m−1, outperforming conventional chitosan, cellulose, agarose, starch, and gelatin based ionic hydrogels.
Baojin Chen +7 more
wiley +1 more source