Results 31 to 40 of about 597,674 (298)

Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors

Frontiers in Cellular Neuroscience, 2015
Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang, Michael K Tian, Craig D. C. Bailey, Craig D. C. Bailey, Evelyn K Lambe, Evelyn K Lambe, Evelyn K Lambe   +6 more
doaj   +1 more source

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Alcohol and nicotinic acetylcholine receptors [PDF]

QScience Connect, 2013
Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neurological mechanisms. For example, nicotine acts on Nicotinic acetylcholine receptors (nAChRs) in the brain to release dopamine to sustain addiction. Might
Jinsong Tang, Yanhui Liao
doaj   +1 more source

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions

Pharmacological Research, 2023
Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
doaj   +1 more source

Heterogenous Cholinergic Nicotinic Receptors in the CNS

, 1988
Multiple nicotinic binding sites are found in mammalian brain. Several nicotinic agonists and antagonists have been used to characterize the nicotinic binding sites.
Nilsson, L, Abdu Adem, Luciana Romanelli, Nordberg, A, Lena Nilsson, Adem, A, Xiao Zhang, Zhang, X, Agneta Nordberg, Romanelli, L   +9 more
core   +1 more source

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

Variants in Nicotinic Receptors and Risk for Nicotine Dependence [PDF]

American Journal of Psychiatry, 2008
A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly ...
Laura Jean, Bierut, Jerry A, Stitzel, Jen C, Wang, Anthony L, Hinrichs, Richard A, Grucza, Xiaoling, Xuei, Nancy L, Saccone, Scott F, Saccone, Sarah, Bertelsen, Louis, Fox, William J, Horton, Naomi, Breslau, John, Budde, C Robert, Cloninger, Danielle M, Dick, Tatiana, Foroud, Dorothy, Hatsukami, Victor, Hesselbrock, Eric O, Johnson, John, Kramer, Samuel, Kuperman, Pamela A F, Madden, Kevin, Mayo, John, Nurnberger, Ovide, Pomerleau, Bernice, Porjesz, Oliver, Reyes, Marc, Schuckit, Gary, Swan, Jay A, Tischfield, Howard J, Edenberg, John P, Rice, Alison M, Goate   +32 more
openaire   +2 more sources

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]

, 2009
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes, Caroline Nothdurfter, Tanasic, S., Rammes, G., Rupprecht, R., Eisensamer, Brigitte, Zieglgänsberger Walter, Christine Hosp, Tanasic, Sascha, Hosp Christine, Walter Zieglgänsberger, Rupprecht Rainer, Rammes, Gerhard, Sascha Tanasic, Hosp, C., Rammes Gerhard, Nothdurfter, C., Tanasic Sascha, Rupprecht, Rainer, Nothdurfter Caroline, Brigitte Eisensamer, Eisensamer, B., Zieglgänsberger, Walter, Zieglgänsberger, W., Hosp, Christine, Rainer Rupprecht, Nothdurfter, Caroline, Eisensamer Brigitte   +27 more
core   +2 more sources

Nicotine dependence and genetic variation in the nicotinic receptors [PDF]

Drug and Alcohol Dependence, 2009
Technological advances have led to the discovery of genetic variants that contribute to many illnesses including nicotine dependence. A multi-stage model of the development of nicotine dependence underlies these genetic studies, and it includes a progression through several stages of smoking behavior from never smoking to nicotine dependence. The final
openaire   +2 more sources