Results 11 to 20 of about 597,674 (298)

Nicotinic Receptors in Neurodegeneration [PDF]

Current Neuropharmacology, 2013
Many studies have focused on expanding our knowledge of the structure and diversity of peripheral and central nicotinic receptors. Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C), serotonin, and glycine receptors.
Posadas, Inmaculada, López-Hernández, Beatriz, Ceña, Valentín   +2 more
openaire   +2 more sources

Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]

Veterinarski Glasnik, 2010
Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M., Ivanović Saša R., Trailović-Nedeljković Jelena, Robertson Alan P.   +3 more
doaj   +1 more source

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype [PDF]

Journal of Biological Chemistry, 2008
Recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. Using heterologous expression, we found that alpha6beta2, like alpha3beta2 and alpha4beta2 receptors, formed high affinity epibatidine ...
Heather, Walsh, Anitha P, Govind, Ryan, Mastro, J C, Hoda, Daniel, Bertrand, Yolanda, Vallejo, William N, Green   +6 more
openaire   +2 more sources

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]

PLoS ONE, 2015
Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersall   +8 more
doaj   +1 more source

Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. [PDF]

PLoS ONE, 2016
Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance.
Melanie Abongwa, Samuel K Buxton, Alan P Robertson, Richard J Martin   +3 more
doaj   +1 more source

Nicotine and nicotinic receptors in the circadian system

Psychoneuroendocrinology, 1998
Considerable data support a role for cholinergic influences on the circadian system. The extent to which these influences are mediated by nicotinic acetylcholine receptors (nAChRs) has been controversial, as have the specific actions of nicotine and acetylcholine in the suprachiasmatic nucleus (SCN) of the hypothalamus.
B F, O'Hara, D M, Edgar, V H, Cao, S W, Wiler, H C, Heller, T S, Kilduff, J D, Miller   +6 more
openaire   +2 more sources

Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex [PDF]

, 2011
The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infusion into the ...
Warburton, E Clea, Endean, E. P. E., Fontaine-Palmer, N. S., Chris J. Tinsley, Endean, Emma P E, Aggleton, John P, John P. Aggleton, Emma P.E. Endean, Vincent, Maria, Aggleton, John Patrick, Maria Vincent, E. Clea Warburton, Nadine S. Fontaine-Palmer, Brown, M. W., Malcolm W. Brown, Tinsley, Chris J, Brown, Malcolm W, Vincent, M., Tinsley, C. J., Fontaine-Palmer, Nadine S, Warburton, E. C.   +20 more
core   +1 more source

Cloning and characterization of the hamster and guinea pig nicotinic acid receptors

Journal of Lipid Research, 2007
In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares ∼80–90% identity with the nucleotide and amino acid sequences of human, mouse, and rat receptors. The guinea
April Smith Torhan, Boonlert Cheewatrakoolpong, Lia Kwee, Scott Greenfeder   +3 more
doaj   +1 more source

NICOTINIC RECEPTORS IN NEUROPSYCHIATRIC PATHOLOGIES OF ADULTHOOD AND DEVELOPMENTAL AGE. [PDF]

Euromediterranean Biomedical Journal, 2013
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels present in many regions of the central nervous system (CNS) and the peripheral nervous system.
Elettra Unti
doaj   +1 more source

Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

Pharmacological Research, 2023
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system.
Katrin Richter, Veronika Grau
doaj   +1 more source