Results 51 to 60 of about 6,176 (139)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The Paradox of Feline Coronavirus Pathogenesis: A Review

Advances in Virology, 2011
Feline coronavirus (FCoV) is an enveloped single-stranded RNA virus, of the family Coronaviridae and the order Nidovirales. FCoV is an important pathogen of wild and domestic cats and can cause a mild or apparently symptomless enteric infection ...
Luciana Wanderley Myrrha, Fernanda Miquelitto Figueira Silva, Ethel Fernandes de Oliveira Peternelli, Abelardo Silva Junior, Maurício Resende, Márcia Rogéria de Almeida   +5 more
doaj   +1 more source

Vector competence of anthropophilic mosquitoes for a new mesonivirus in Senegal

Emerging Microbes and Infections, 2020
The mesoniviruses (MESOVs) belong to the newly described Mesoniviridae family (Order: Nidovirales). They have never been reported in Senegal until recently during a study in arbovirus emergence with the detection of a new species of MESOV named Dianke ...
Alioune Gaye, Moussa Moïse Diagne, El Hadji Ndiaye, Marie Henriette Dior Ndione, Martin Faye, Cheikh Talla, Gamou Fall, Yamar Ba, Diawo Diallo, Ibrahima Dia, Pascal Handschumacher, Ousmane Faye, Amadou Alpha Sall, Mawlouth Diallo   +13 more
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Identification of aNidoviralesOrf1a N7-guanine cap Methyltransferase signature-sequence as a genetic marker of large genomeTobaniviridae [PDF]

, 2019
AbstractMembers of theNidoviralesorder have (+)RNA genomes amongst the largest in size in the RNA virus world. Expression of their genes is promoted through reading of genomic RNA and mRNA transcripts by the ribosome of the infected cell. The 5’-end of these RNAs is supposedly protected by an RNA-cap structure (m7GpppNm) whose most synthesis steps ...
Ferron, François, Debat, Humberto Julio, Decroly, Etienne, Canard, Bruno   +3 more
openaire   +1 more source

Complete Genome Sequence of Macrobrachium rosenbergii Golda Virus (MrGV) from China

Animals, 2021
In a meta-transcriptome study of the giant freshwater prawn Macrobrachium rosenbergii sampled in 2018 from a hatchery, we identified a variant of Macrobrachium rosenbergii golda virus (MrGV) in postlarvae without clinical signs.
Fanzeng Meng, Yiting Wang, Guohao Wang, Tao Hu, La Xu, Kathy F. J. Tang, Weifeng Shi, Fan Zhang, Xuan Dong, Jie Huang   +9 more
doaj   +1 more source

Remdesivir in COVID‐19: A Focus on Pediatric Cardiac Patients

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
The coronavirus disease 2019 (COVID‐19) pandemic has presented a significant global health challenge that necessitated the immediate search for various therapeutic modalities. Remdesivir, an antiviral drug inhibiting RNA‐dependent RNA polymerase (RdRp), was among the most heavily used drugs against COVID‐19.
Dima Bsat, Dalia Safi, Mariam Arabi, Mamunur Rahman Malik   +3 more
wiley   +1 more source

Evidence for a novel coding sequence overlapping the 5'-terminal ~90 codons of the Gill-associated and Yellow head okavirus envelope glycoprotein gene

Virology Journal, 2009
The genus Okavirus (order Nidovirales) includes a number of viruses that infect crustaceans, causing major losses in the shrimp industry. These viruses have a linear positive-sense ssRNA genome of ~26-27 kb, encoding a large replicase polyprotein that is
Atkins John F, Firth Andrew E
doaj   +1 more source

A Natural Recombinant NADC30‐Like PRRSV Strain in China: Intersection of CH‐1a, QYYZ, and JXA1 Lineages

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to global swine production. In this study, a novel strain (PRRSV‐AH1) was isolated during a respiratory disease outbreak at a commercial swine operation in Anhui Province, China. Viral replication in MARC‐145 cells was confirmed by observing cytopathic effects (CPEs) and
Heng Zhang, Chengxin Zhang, Yingru Ma, Qin Zhao, Ximei Wang, Qing Pan, Yani Sun, Nan-hua Chen   +7 more
wiley   +1 more source