Results 81 to 90 of about 6,176 (139)

Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New Thiazolidinone Derivatives as NNRTIs and SARS‐CoV‐2 Main Protease Inhibitors

Chemistry &Biodiversity, Volume 21, Issue 12, December 2024.
Abstract HIV‐1 remains a major health problem worldwide since the virus has developed drug‐resistant strains, so, the need for novel agents is urgent. The protein reverse transcriptase plays fundamental role in the viruses’ replication cycle. FDA approved Delavirdine bearing a sulfonamide moiety, while thiazolidinone has demonstrated significant anti ...
Maria Fesatidou, Anthi Petrou, Athina Geronikaki   +2 more
wiley   +1 more source

Growth enhancement of porcine epidemic diarrhea virus (PEDV) in Vero E6 cells expressing PEDV nucleocapsid protein.

PLoS ONE, 2019
More recently emerging strains of porcine epidemic diarrhea virus (PEDV) cause severe diarrhea and especially high mortality rates in infected piglets, leading to substantial economic loss to worldwide swine industry.
Benjamas Liwnaree, Jaraspim Narkpuk, Suttipun Sungsuwan, Anan Jongkaewwattana, Peera Jaru-Ampornpan   +4 more
doaj   +1 more source

Laboratory Detection of Novel Corona Virus 2019 using Polymerase Chain Reaction

The International Journal of Frontier Sciences
Since mid-December 2019, several cases of a pneumonia like disease (with symptoms including fever, difficulty in breathing, cough and invasive lesions on both lungs) of unknown cause have emerged in the central Chinese city of Wuhan. Chinese authorities
Shafiq Ahmad Chudhary, Shahid Imtiaz, Nedal Iqbal   +2 more
doaj   +1 more source

Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication.

PLoS ONE, 2019
Autophagy is a conserved eukaryotic process that mediates lysosomal degradation of cytoplasmic macromolecules and damaged organelles, also exerting an important role in the elimination of intracellular pathogens.
Ginés Ávila-Pérez, Elisabet Diaz-Beneitez, Liliana L Cubas-Gaona, Gliselle Nieves-Molina, Juan Ramón Rodríguez, José F Rodríguez, Dolores Rodríguez   +6 more
doaj   +1 more source

Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication.

PLoS ONE, 2008
Analyses of viral protein-protein interactions are an important step to understand viral protein functions and their underlying molecular mechanisms. In this study, we adopted a mammalian two-hybrid system to screen the genome-wide intraviral protein ...
Ji'an Pan, Xiaoxue Peng, Yajing Gao, Zhilin Li, Xiaolu Lu, Yingzhao Chen, Musarat Ishaq, Dan Liu, Marta L Dediego, Luis Enjuanes, Deyin Guo   +10 more
doaj   +1 more source

Virus-encoded proteinases and proteolytic processing in the Nidovirales

Journal of General Virology, 2000
J, Ziebuhr, E J, Snijder, A E, Gorbalenya   +2 more
openaire   +2 more sources

Unveiling the structural and functional implications of uncharacterized NSPs and variations in the molecular toolkit across arteriviruses. [PDF]

NAR Genom Bioinform
Rakesh S, Behera K, Krishnan A.
europepmc   +1 more source

Genome sizes of animal RNA viruses reflect phylogenetic constraints. [PDF]

Virus Evol
Takada K, Holmes EC.
europepmc   +1 more source

Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality. [PDF]

Proc Natl Acad Sci U S A
Zhong KX, Chan AM, Miller KM, Saunders R, Suttle CA.   +4 more
europepmc   +1 more source

Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway. [PDF]

Viruses
Yang Y, Li X, Shi H, Yu J, Gao C, Liu Y, Feng W, Peng L, Fu B, Yi P.   +9 more
europepmc   +1 more source