Baculovirus Utilizes Cholesterol Transporter NIEMANN–Pick C1 for Host Cell Entry [PDF]
Frontiers in Microbiology, 2019 The dual roles of baculovirus for the control of natural insect populations as an insecticide, and as a tool for foreign gene expression and delivery, have called for a comprehensive understanding of the molecular mechanisms governing viral infection ...
Zhihong Li +32 more
doaj +2 more sources
Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation [PDF]
iScience, 2023 Summary: Niemann-Pick disease type C (NP-C) is a genetic lysosomal disorder associated with progressive neurodegenerative phenotypes. Its therapeutic options are very limited.
Shiqian Han +14 more
doaj +2 more sources
Advances in research on potential therapeutic approaches for Niemann-Pick C1 disease [PDF]
Frontiers in PharmacologyNiemann-Pick disease type C1 (NP-C1) is a rare and devastating recessive inherited lysosomal lipid and cholesterol storage disorder caused by mutations in the NPC1 or NPC2 gene.
Caifeng Zhang +8 more
doaj +2 more sources
Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study [PDF]
Viruses, 2021 Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi +3 more
doaj +2 more sources
A hopeful therapy for Niemann-Pick C diseases [PDF]
Lancet, The, 2017 Not abstract ...
Erickson, Robert P. +1 more
core +3 more sources
Olfactory deficits in Niemann-Pick type C1 (NPC1) disease.
PLoS ONE, 2013 BackgroundNiemann-Pick type C disease (NPC) is a rare autosomal recessive lipid storage disease characterized by progressive neurodegeneration. As only a few studies have been conducted on the impact of NPC on sensory systems, we used a mutant mouse ...
Marina Hovakimyan +8 more
doaj +4 more sources
Precision Medicine in Cats: Novel Niemann‐Pick Type C1 Diagnosed by Whole‐Genome Sequencing [PDF]
Journal of Veterinary Internal Medicine, 2017 State‐of‐the‐art health care includes genome sequencing of the patient to identify genetic variants that contribute to either the cause of their malady or variants that can be targeted to improve treatment.
D.A. Mauler +6 more
doaj +2 more sources
EBioMedicine, 2016 Niemann Pick type C (NP-C) is a rare neurodegenerative disorder caused by an impairment of intracellular lipid transport. Due to the heterogeneous clinical phenotype and the lack of a reliable blood test, diagnosis and therapy are often delayed for years.
Janine Reunert +7 more
doaj +3 more sources
Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling [PDF]
Journal of Lipid Research, 2013 Niemann-Pick type C (NPC)1 is a rare neurodegenerative disease for which treatment options are limited. A major barrier to development of effective treatments has been the lack of validated biomarkers to monitor disease progression or serve as outcome ...
Martin Fan +12 more
doaj +3 more sources
Accumulation of alkyl-lysophosphatidylcholines in Niemann-Pick disease type C1
Journal of Lipid ResearchLysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol.
Sonali Mishra +10 more
doaj +3 more sources