Results 191 to 200 of about 15,838 (212)
Some of the next articles are maybe not open access.
Purification and Characterization of Human Niemann–Pick C1 Protein
2019Niemann-Pick C1 (NPC1) is a membrane protein required for the transport of low-density lipoprotein (LDL)-derived cholesterol from endosomes and lysosomes to the other organelles. Here, we describe the recombinant protein expression, purification, and characterization of the human NPC1. The protein is transiently expressed in human embryonic kidney (HEK)
Xin, Gong, Hongwu, Qian
openaire +2 more sources
Niemann‐Pick C1‐like 1 Promotes Intestinal Absorption of Siphonaxanthin
Lipids, 2019AbstractSiphonaxanthin is a carotenoid found in certain green algae, and its promising beneficial properties, such as its anti‐obesity effect, have recently been demonstrated. However, there is little information about the molecular mechanisms underlying intestinal absorption of siphonaxanthin. In this study, we aimed to elucidate how siphonaxanthin is
Yuki Manabe +9 more
openaire +2 more sources
Niemann–Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009Niemann-Pick C1 Like 1 (NPC1L1) has been identified and characterized as an essential protein in the intestinal cholesterol absorption process. NPC1L1 localizes to the brush border membrane of absorptive enterocytes in the small intestine. Intestinal expression of NPC1L1 is down regulated by diets containing high levels of cholesterol.
Harry R, Davis, Scott W, Altmann
openaire +2 more sources
The Structure and Function of the Niemann–Pick C1 Protein
Molecular Genetics and Metabolism, 2000Niemann-Pick C (NPC) disease is a recessive cholesterol storage disorder characterized by severe, progressive neurodegeneration. The primary causative gene found on chromosome 18q11-12 was identified by a positional cloning approach. The NPC1 gene product is predicted to be a large polytopic glycoprotein with a cytoplasmic tail containing a dileucine ...
openaire +2 more sources
CRISPR/Cas9-Mediated Generation of Niemann–Pick C1 Knockout Cell Line
2017Generating a cholesterol storage phenotype of Niemann-Pick Type C (NPC) disease is important for investigating the mechanisms of intracellular cholesterol trafficking, as well as screening drugs for potential treatment of NPC disease. The use of the CRISPR/Cas9 technology to knockout specific genes within the genome of mammals has become routine in the
Ximing, Du +2 more
openaire +2 more sources
Gene Therapy Moves Forward for Niemann–Pick Disease Type C1
Human Gene Therapy, 2021openaire +2 more sources
Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
Cell, 2019Mikael Becher Lykkegaard Winkler +2 more
exaly
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1
Cell, 2016Han Wang, Yi Shi, Jian Song
exaly