Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease. [PDF]
Proceedings of the National Academy of Sciences, 1999 Niemann–Pick type C disease (NP-C) is an inherited neurovisceral lipid storage disorder characterized by progressive neurodegeneration. Most cases of NP-C result from inactivating mutations of NPC1 , a recently identified member of a family of genes encoding membrane-bound proteins containing putative sterol ...
Shutish C. Patel +11 more
semanticscholar +3 more sources
Nature CommunicationsSARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2 (ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor.
Ilyas Khan +17 more
doaj +2 more sources
Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK [PDF]
Autophagy, 2017 Austin, Christopher P. +8 more
core +4 more sources
Correction: The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.
PLoS ONE, 2014 doaj +11 more sources
Molecular Biology of the Cell, 2001 People homozygous for mutations in the Niemann-Pick type C1 (NPC1) gene have physiological defects, including excess accumulation of intracellular cholesterol and other lipids, that lead to drastic neural and liver degeneration. The NPC1 multipass transmembrane protein is resident in late endosomes and lysosomes, but its functions are unknown.
Dennis C. Ko +3 more
semanticscholar +4 more sources
Porcine Niemann Pick-C1 Protein Is Expressed in Steroidogenic Tissues and Modulated by cAMP. [PDF]
Endocrinology, 2002 Niemann-Pick C-1 (NPC-1) protein is essential for trafficking of low density lipoprotein-derived cholesterol in mammalian cells. The low density lipoprotein pathway is a major route for supply of cholesterol for steroidogenesis in the adrenals and gonads of many species.
Nicolas Ge Vry +5 more
semanticscholar +5 more sources
Copper incorporation into ceruloplasmin is regulated by Niemann–Pick C1 protein
Hepatology Research, 2011 Aim: Wilson disease is a genetic disorder of copper metabolism characterized by impaired biliary copper excretion. Wilson disease gene product (ATP7B) functions in copper incorporation to ceruloplasmin (Cp) and biliary copper excretion. Our previous study showed the late endosome localization of ATP7B and described the copper transport pathway from the
C. Yanagimoto +13 more
semanticscholar +3 more sources
Ncr1p, the Yeast Ortholog of Mammalian Niemann Pick C1 Protein, is Dispensable for Endocytic Transport [PDF]
Traffic, 2004 The Niemann Pick C1 protein localizes to late endosomes and plays a key role in the intracellular transport of cholesterol in mammalian cells. Cholesterol and other lipids accumulate in a lysosomal or late endosomal compartment in cells lacking normal NPC1 function.
Shaochong Zhang +6 more
semanticscholar +4 more sources
Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein [PDF]
Hepatology, 2012 The hepatic expression of Niemann-Pick C1-like 1 (NPC1L1), which is a key molecule in intestinal cholesterol absorption, is high in humans. In addition to NPC1L1, Niemann-Pick C2 (NPC2), a secretory cholesterol-binding protein involved in intracellular cholesterol trafficking and the ...
Yoshihide, Yamanashi +3 more
openaire +2 more sources
Intestinal and Hepatic Niemann-Pick C1-Like 1 [PDF]
Diabetes & Metabolism Journal, 2013 Polytopic transmembrane protein, Niemann-Pick C1-Like 1 (NPC1L1) is localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes.
Sung-Woo Park
doaj +1 more source