Results 1 to 10 of about 331,853 (179)
Tom40 in cholesterol transport [PDF]
iScience, 2023 Summary: Cholesterol initiates steroid metabolism in adrenal and gonadal mitochondria, which is essential for all mammalian survival. During stress an increased cholesterol transport rapidly increases steroidogenesis; however, the mechanism of ...
Himangshu S. Bose +2 more
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Nonvesicular cholesterol transport in physiology [PDF]
The Journal of Clinical InvestigationIn mammalian cells cholesterol can be synthesized endogenously or obtained exogenously through lipoprotein uptake. Plasma membrane (PM) is the primary intracellular destination for both sources of cholesterol, and maintaining appropriate membrane ...
Alessandra Ferrari, Peter Tontonoz
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Is reverse cholesterol transport regulated by active cholesterol? [PDF]
Journal of Lipid Research, 2023 This review considers the hypothesis that a small portion of plasma membrane cholesterol regulates reverse cholesterol transport in coordination with overall cellular homeostasis.
Theodore L. Steck, Yvonne Lange
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Intracellular cholesterol transport
Journal of Lipid Research, 1997 Recent data on the roles of vesicle- and ‘raft‘-mediated pathways in intracellular free cholesterol (FC) transport are reviewed. Cholesterol internalized from plasma lipoproteins is transferred via endocytic vesicles to the trans-Golgi network (TGN ...
C J Fielding, P E Fielding
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Intracellular cholesterol transport.
Journal of Lipid Research, 1992 The intracellular movement of cholesterol in mammalian cells may involve complex pathways by which the sterol moves to various cellular sites and mediates transcriptional regulation, enzyme activation, and protein degradation.
L Liscum, NK Dahl
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A new perspective on the regulation of glucose and cholesterol transport by mitochondria-lysosome contact sites [PDF]
Frontiers in PhysiologyMitochondria and lysosomes play a very important role in maintaining cellular homeostasis, and the dysfunction of these organelles is closely related to many diseases.
Xiaolong Chen +5 more
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Intracellular Cholesterol Synthesis and Transport
Frontiers in Cell and Developmental Biology, 2022 Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases.
Qingyang Shi +4 more
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IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi. [PDF]
PLoS Pathogens, 2023 Aichi virus (AiV), a small non-enveloped RNA virus, hijacks the endoplasmic reticulum (ER)-Golgi cholesterol transport machinery to form cholesterol-rich replication sites originating from Golgi membranes.
Kumiko Ishikawa-Sasaki +2 more
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Bafilomycin A1 Inhibits HIV-1 Infection by Disrupting Lysosomal Cholesterol Transport [PDF]
VirusesThe productive replication of human immunodeficiency virus type 1 (HIV-1) involves intricate interactions between viral proteins and host cell machinery. However, the contributions of the lysosomal pathways for HIV-1 replication are not fully understood.
Byeongwoon Song, Olga Korolkova
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Intracellular cholesterol transport [PDF]
Journal of Clinical Investigation, 2002 Cholesterol is the single most abundant lipid species in mammalian cells. More than 2×109 years of evolution designed this molecule to perfectly fit into phospholipid bilayers regulating the fluidity, permeability and bending stiffness of biological membranes.
Frederick R, Maxfield, Daniel, Wüstner
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