Results 11 to 20 of about 331,972 (296)
Intracellular Cholesterol Transport [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Intracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis. Many aspects of cholesterol metabolism are well-known, including its synthesis in the endoplasmic reticulum, its extracellular transport in plasma lipoproteins, its uptake by the low-density lipoprotein receptor, and its regulation of SREBP and LXR ...
Raymond E, Soccio, Jan L, Breslow
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The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection
Viruses, 2022 Many viruses require the maintenance of lysosomal cholesterol homeostasis for a successful infection; however, the role of lysosomal cholesterol homeostasis in the alphaherpesvirus life cycle is not clear.
Byeongwoon Song
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Frontiers in Aging Neuroscience, 2022 Palmitoylation is a dynamic process that regulates the activity of the modified proteins. Retinal pigment epithelial (RPE) cells play pivotal roles in the visual cycle and maintaining healthy photoreceptor cells.
Jia Kai Li +7 more
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Journal of Lipid Research, 2023 Human female infertility, 20% of which is idiopathic, is a public health problem for which better diagnostics and therapeutics are needed. A novel cause of infertility emerged from studies of female mice deficient in the HDL receptor gene (Scarb1). These
Corina Rosales +5 more
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NPC1L1 and cholesterol transport [PDF]
FEBS Letters, 2010 The polytopic transmembrane protein, Niemann–Pick C1‐Like 1 (NPC1L1), is enriched in the apical membrane of small intestine absorptive enterocytes where it mediates extracellular sterol transport across the brush border membrane. It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption ...
Betters, Jenna L., Yu, Liqing
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Does the Actin Network Architecture Leverage Myosin-I Functions?
Biology, 2022 The actin cytoskeleton plays crucial roles in cell morphogenesis and functions. The main partners of cortical actin are molecular motors of the myosin superfamily.
Julien Pernier, Kristine Schauer
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Lipids in Entamoeba histolytica: Host-Dependence and Virulence Factors
Frontiers in Cellular and Infection Microbiology, 2020 Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate ...
Silvia Castellanos-Castro +4 more
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Coming Back to Physiology: Extra Hepatic Functions of Proprotein Convertase Subtilisin/Kexin Type 9
Frontiers in Physiology, 2020 Neuronal apoptosis regulated convertase-1 (NARC-1), now mostly known as proprotein convertase subtilisin/kexin type 9 (PCSK9), has received a lot of attention due to the fact that it is a key regulator of the low-density lipoprotein (LDL) receptor (LDL-R)
Klaus-Dieter Schlüter +2 more
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Reverse cholesterol transport [PDF]
Cor et Vasa, 2006 Atherosclerosis, the accumulation of cholesterol in the arteries resulting in heart attacks and strokes, is the leading cause of death in the USA and most other industrialized countries in the world. Plasma levels of high-density lipoprotein (HDL) cholesterol are invariably found to be inversely associated with the risk of atherosclerosis.
Ivana Králová Lesná +2 more
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Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1 [PDF]
, 2017 Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell.
Abramson, Jeff +10 more
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