Results 51 to 60 of about 16,701 (225)

Niemann-Pick type C1 protein influences the delivery of cholesterol to the SREBP: SCAP complex [PDF]

Brazilian Journal of Medical and Biological Research, 2008
The proposed role of Niemann-Pick type C1 protein (NPC1) in the delivery of low-density lipoprotein (LDL) cholesterol to the sterol regulatory element binding protein (SREBP):SREBP cleavage activation protein (SCAP) complex in the endoplasmic reticulum has been largely based on indirect studies and remains contentious.
Y.J. Guo, W.H. Li, R. Wu, Q. Xie, Z.H. Zhang, L.Q. Cui   +5 more
doaj   +5 more sources

The role of NPC1L1 in cancer

Frontiers in Pharmacology, 2022
Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part
Renshuai Zhang, Jun Zeng, Jun Zeng, Wenjing Liu, Wenjing Liu, Jingsen Meng, Jingsen Meng, Chao Wang, Lingyu Shi, Lingyu Shi, Shanbo Yang, Shanbo Yang, Jing Chang, Jing Chang, Dongming Xing, Dongming Xing   +15 more
doaj   +1 more source

Mechanisms of Niemann-Pick type C1 Like 1 protein degradation in intestinal epithelial cells [PDF]

American Journal of Physiology-Cell Physiology, 2019
Intestinal Niemann-Pick C1 Like 1 (NPC1L1) protein plays a key role in cholesterol absorption. A decrease in NPC1L1 expression has been implicated in lowering plasma cholesterol and mitigating the risk for coronary heart disease. Little is known about the mechanisms responsible for NPC1L1 protein degradation that upon activation may lead to a ...
Pooja, Malhotra, Vinay, Soni, Yoshihide, Yamanashi, Tappei, Takada, Hiroshi, Suzuki, Ravinder K, Gill, Seema, Saksena, Pradeep K, Dudeja, Waddah A, Alrefai   +8 more
openaire   +2 more sources

Recovery from liver disease in a Niemann-Pick type C mouse model

Journal of Lipid Research, 2010
Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease.
Naomi L. Sayre, Victoria M. Rimkunas, Mark J. Graham, Rosanne M. Crooke, Laura Liscum   +4 more
doaj   +1 more source

The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. [PDF]

PLoS ONE, 2016
Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years.
Jian Wu, Wei Cui, Qu Cai, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han, Hai Hu, Zhao-Yan Jiang   +7 more
doaj   +1 more source

Fostering collaborative research for rare genetic disease: The example of Niemann-Pick type C disease [PDF]

, 2016
Rare disease represents one of the most significant issues facing the medical community and health care providers worldwide, yet the majority of these disorders never emerge from their obscurity, drawing little attention from the medical community or the
Austin, Christopher P, Davidson, Cristin D, Jacoby, Jonathan, Marella, Philip D, Ory, Daniel S, Ottinger, Elizabeth A, Porter, Forbes D, Vite, Charles H, Walkley, Steven U   +8 more
core   +2 more sources

Faculty of 1000 evaluation for Structure of human Niemann-Pick C1 protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
B. Borroni
semanticscholar   +2 more sources

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]

, 2017
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson, Andrade-Neto, Antoine, Bansal, Berman, Blanchette-Mackie, Burack, Carstea, Carvalho, Chakraborty, Chattopadhyay, Collins, Coombs, Coppens, De Cicco, Desvergne, Duclos, Edwards, Ehrenman, Fernandes, Ghosh, Ghosh, Ghosh, Ginger, Ginger, Goldstein, Groener, Hamid, Hart, Ikonen, Infante, Johndrow, Kima, Kima, Kok, Kwon, Lal, Lecoeur, Lippuner, Livak, Majumder, Maxfield, McIntosh, Misslitz, Naureckiene, Neufeld, Osorio y Fortea, Ovalle-Bracho, Paape, Paape, Pereira, Portugal, Pucadyil, Rabhi, Redgrave, Roberts, Rosenzweig, Rub, Russell, Saunders, Sen, Shamshiev, Soares, Sorensen, Tetley, Tewary, Tontonoz, Weinheber   +67 more
core   +2 more sources

Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

iScience, 2022
Summary: Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Building on our previous studies of the neurodegenerative
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou   +17 more
doaj   +1 more source

Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review [PDF]

, 2016
Niemann-Pick disease type C (NP-C) is a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder caused by mutations in one of the two genes, NPC1 or NPC2. Diagnosis has often been a difficult task, due to the wide range in age of onset
Bauer, P, Burlina, A, Coll, MJ, Gissen, P, Goizet, C, Hendriksz, CJ, Kolb, SA, Latour, P, Marquardt, T, Vanier, MT, Welford, RWD   +10 more
core   +2 more sources