Results 81 to 90 of about 16,701 (225)

The role of cellular adhesion molecules in virus attachment and entry [PDF]

, 2015
As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core   +1 more source

Fatty acid metabolism—an emerging regulatory node in T‐cell immunometabolism

Clinical &Translational Immunology, Volume 15, Issue 4, 2026.
Abstract While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T‐cell biology.
Brett Chapel Arenberg, Michael N Sack, Jing Wu   +2 more
wiley   +1 more source

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study [PDF]

, 2017
Additional file 1.
Carmen Dominguez, Isabel De Castro-Orós, Jorge Javier Cebolla, María Jesús Pueyo, Miguel Mallén, Miguel Pocoví, null null, Pilar Irún, Pilar Mozas, Victor Rodriguez-Sureda   +9 more
core   +3 more sources

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

Cell Reports, 2013
Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not clear.
Sovan Sarkar, Bernadette Carroll, Yosef Buganim, Dorothea Maetzel, Alex H.M. Ng, John P. Cassady, Malkiel A. Cohen, Souvik Chakraborty, Haoyi Wang, Eric Spooner, Hidde Ploegh, Joerg Gsponer, Viktor I. Korolchuk, Rudolf Jaenisch   +13 more
doaj   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling [PDF]

, 2013
Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined cellular uptake of siRNA delivered in
A Akinc, Ahmed Eltoukhy, Avi Schroeder, B Ravikumar, C Collinet, C Sheridan, CA Alabi, Christopher Alabi, Christopher Zurenko, D Chen, Daniel G Anderson, DC Ko, Delai Chen, DJ Gibbings, E Ikonen, Emmanouil Karagiannis, F Leuschner, G Basha, G Sahay, Gaurav Sahay, GJ Doherty, H Siomi, H Stenmark, IA Khalil, J Nguyen, J Suh, J Wang, JE Carette, JJ Lu, KA Whitehead, Kevin Love, KT Love, L Stalder, M Huss, M Hölttä-Vuori, M Koivusalo, M Ostrowski, M Zhang, MD Linder, ME Davis, N Bayer, ND Sonawane, P Shannon, R Zoncu, RL Juliano, Robert Langer, Roberto Zoncu, S Maere, S Sarkar, SK Lai, SM Elbashir, Sovan Sarkar, William Querbes, Yosef Buganim, YS Lee   +54 more
core   +2 more sources

Metaproteome Analysis of Short‐Term Thermal Stress in Three Sympatric Coral Species Reveals Divergent Host Responses

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Short‐term thermal stress triggers distinct molecular responses in three sympatric coral species with contrasting thermal resilience. Proteomic and metabolomic profiling reveal both species‐specific and limited shared pathways underlying these stress responses.
Shrinivas Nandi, Timothy G. Stephens, Erin E. Chille, Samantha Goyen, Line K. Bay, Debashish Bhattacharya   +5 more
wiley   +1 more source

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]

, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson, Allison, Almeida, Amman, Amman, Baker, Biesold, Bolger, Carette, Carroll, Carstea, Chandran, Cui, Côté, Daugherty, Deffieu, Delport, Demogines, Demogines, Drexler, Ebihara, Feldmann, Ge, Gire, Grabherr, He, Herbert, Hueffer, Jahrling, Jangra, Jayme, Jones, Kaelber, Kamins, Katzourakis, Krishnan, Kugelman, Kuhn, Kühl, Lee, Leroy, Li, Mali, Maruyama, Meyerson, Miller, Miller, Miller-Butterworth, Murrell, Negredo, Ng, Olival, Park, Parker, Paweska, Peel, Pond, Radoshitzky, Radoshitzky, Raj, Ren, Robertson, Ross, Runz, Ruxton, Sheahan, Swenson, Swenson, Takada, Taylor, Taylor, Taylor, Tong, Towner, Vanier, Volchkov, Wahl-Jensen, Wong, Yang   +78 more
core   +2 more sources

Molecular Characterisation of Niemann Pick Type C1 Protein

, 2014
Niemann-Pick disease type C (NPC) is a fatal neurodegenerative disorder characterised by accumulation of free cholesterol and glycosphingolipids in the late endosome (LE) and lysosome (Ly). Loss-of-function mutations in the NPC1 gene account for as high as 95% incidence among all NPC cases.
openaire   +2 more sources